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Echocardiographic Assessment of Ventricular Function in Young Patients with Asthma
BACKGROUND: Despite significant advances in understanding the pathophysiology and management of asthma, some of systemic effects of asthma are still not well defined. OBJECTIVES: To compare heart function, baseline physical activity level, and functional exercise capacity in young patients with mild...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Cardiologia - SBC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898772/ https://www.ncbi.nlm.nih.gov/pubmed/29694547 http://dx.doi.org/10.5935/abc.20180052 |
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author | De-Paula, Camilla Rayane Magalhães, Giselle Santos Jentzsch, Nulma Souto Botelho, Camila Figueredo Mota, Cleonice de Carvalho Coelho Murça, Tatiane Moisés Ramalho, Lidiana Fatima Correa Tan, Timothy C. Capuruço, Carolina Andrade Braganca Rodrigues-Machado, Maria da Gloria |
author_facet | De-Paula, Camilla Rayane Magalhães, Giselle Santos Jentzsch, Nulma Souto Botelho, Camila Figueredo Mota, Cleonice de Carvalho Coelho Murça, Tatiane Moisés Ramalho, Lidiana Fatima Correa Tan, Timothy C. Capuruço, Carolina Andrade Braganca Rodrigues-Machado, Maria da Gloria |
author_sort | De-Paula, Camilla Rayane |
collection | PubMed |
description | BACKGROUND: Despite significant advances in understanding the pathophysiology and management of asthma, some of systemic effects of asthma are still not well defined. OBJECTIVES: To compare heart function, baseline physical activity level, and functional exercise capacity in young patients with mild-to-moderate asthma and healthy controls. METHODS: Eighteen healthy (12.67 ± 0.39 years) and 20 asthmatics (12.0 ± 0.38 years) patients were enrolled in the study. Echocardiography parameters were evaluated using conventional and tissue Doppler imaging (TDI). RESULTS: Although pulmonary acceleration time (PAT) and pulmonary artery systolic pressure (PASP) were within normal limits, these parameters differed significantly between the control and asthmatic groups. PAT was lower (p < 0.0001) and PASP (p < 0.0002) was higher in the asthma group (114.3 ± 3.70 ms and 25.40 ± 0.54 mmHg) than the control group (135.30 ± 2.28 ms and 22.22 ± 0.40 mmHg). The asthmatic group had significantly lower early diastolic myocardial velocity (E', p = 0.0047) and lower E' to late (E'/A', p = 0.0017) (13.75 ± 0.53 cm/s and 1.70 ± 0.09, respectively) compared with control group (15.71 ± 0.34 cm/s and 2.12 ± 0.08, respectively) at tricuspid valve. In the lateral mitral valve tissue Doppler, the asthmatic group had lower E' compared with control group (p = 0.0466; 13.27 ± 0.43 cm/s and 14.32 ± 0.25 cm/s, respectively), but there was no statistic difference in the E'/A' ratio (p = 0.1161). Right isovolumetric relaxation time was higher (p = 0.0007) in asthmatic (57.15 ± 0.97 ms) than the control group (52.28 ± 0.87 ms), reflecting global myocardial dysfunction. The right and left myocardial performance indexes were significantly higher in the asthmatic (0.43 ± 0.01 and 0.37 ± 0.01, respectively) compared with control group (0.40 ± 0.01 and 0.34 ± 0.01, respectively) (p = 0.0383 and p = 0.0059, respectively). Physical activity level, and distance travelled on the six-minute walk test were similar in both groups. CONCLUSION: Changes in echocardiographic parameters, evaluated by conventional and TDI, were observed in mild-to-moderate asthma patients even with normal functional exercise capacity and baseline physical activity level. Our results suggest that the echocardiogram may be useful for the early detection and evoluation of asthma-induced cardiac changes. |
format | Online Article Text |
id | pubmed-5898772 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Sociedade Brasileira de Cardiologia - SBC |
record_format | MEDLINE/PubMed |
spelling | pubmed-58987722018-04-18 Echocardiographic Assessment of Ventricular Function in Young Patients with Asthma De-Paula, Camilla Rayane Magalhães, Giselle Santos Jentzsch, Nulma Souto Botelho, Camila Figueredo Mota, Cleonice de Carvalho Coelho Murça, Tatiane Moisés Ramalho, Lidiana Fatima Correa Tan, Timothy C. Capuruço, Carolina Andrade Braganca Rodrigues-Machado, Maria da Gloria Arq Bras Cardiol Original Articles BACKGROUND: Despite significant advances in understanding the pathophysiology and management of asthma, some of systemic effects of asthma are still not well defined. OBJECTIVES: To compare heart function, baseline physical activity level, and functional exercise capacity in young patients with mild-to-moderate asthma and healthy controls. METHODS: Eighteen healthy (12.67 ± 0.39 years) and 20 asthmatics (12.0 ± 0.38 years) patients were enrolled in the study. Echocardiography parameters were evaluated using conventional and tissue Doppler imaging (TDI). RESULTS: Although pulmonary acceleration time (PAT) and pulmonary artery systolic pressure (PASP) were within normal limits, these parameters differed significantly between the control and asthmatic groups. PAT was lower (p < 0.0001) and PASP (p < 0.0002) was higher in the asthma group (114.3 ± 3.70 ms and 25.40 ± 0.54 mmHg) than the control group (135.30 ± 2.28 ms and 22.22 ± 0.40 mmHg). The asthmatic group had significantly lower early diastolic myocardial velocity (E', p = 0.0047) and lower E' to late (E'/A', p = 0.0017) (13.75 ± 0.53 cm/s and 1.70 ± 0.09, respectively) compared with control group (15.71 ± 0.34 cm/s and 2.12 ± 0.08, respectively) at tricuspid valve. In the lateral mitral valve tissue Doppler, the asthmatic group had lower E' compared with control group (p = 0.0466; 13.27 ± 0.43 cm/s and 14.32 ± 0.25 cm/s, respectively), but there was no statistic difference in the E'/A' ratio (p = 0.1161). Right isovolumetric relaxation time was higher (p = 0.0007) in asthmatic (57.15 ± 0.97 ms) than the control group (52.28 ± 0.87 ms), reflecting global myocardial dysfunction. The right and left myocardial performance indexes were significantly higher in the asthmatic (0.43 ± 0.01 and 0.37 ± 0.01, respectively) compared with control group (0.40 ± 0.01 and 0.34 ± 0.01, respectively) (p = 0.0383 and p = 0.0059, respectively). Physical activity level, and distance travelled on the six-minute walk test were similar in both groups. CONCLUSION: Changes in echocardiographic parameters, evaluated by conventional and TDI, were observed in mild-to-moderate asthma patients even with normal functional exercise capacity and baseline physical activity level. Our results suggest that the echocardiogram may be useful for the early detection and evoluation of asthma-induced cardiac changes. Sociedade Brasileira de Cardiologia - SBC 2018-03 /pmc/articles/PMC5898772/ /pubmed/29694547 http://dx.doi.org/10.5935/abc.20180052 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles De-Paula, Camilla Rayane Magalhães, Giselle Santos Jentzsch, Nulma Souto Botelho, Camila Figueredo Mota, Cleonice de Carvalho Coelho Murça, Tatiane Moisés Ramalho, Lidiana Fatima Correa Tan, Timothy C. Capuruço, Carolina Andrade Braganca Rodrigues-Machado, Maria da Gloria Echocardiographic Assessment of Ventricular Function in Young Patients with Asthma |
title | Echocardiographic Assessment of Ventricular Function in Young
Patients with Asthma |
title_full | Echocardiographic Assessment of Ventricular Function in Young
Patients with Asthma |
title_fullStr | Echocardiographic Assessment of Ventricular Function in Young
Patients with Asthma |
title_full_unstemmed | Echocardiographic Assessment of Ventricular Function in Young
Patients with Asthma |
title_short | Echocardiographic Assessment of Ventricular Function in Young
Patients with Asthma |
title_sort | echocardiographic assessment of ventricular function in young
patients with asthma |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898772/ https://www.ncbi.nlm.nih.gov/pubmed/29694547 http://dx.doi.org/10.5935/abc.20180052 |
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