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Comparative biogeography of the gut microbiome between Jinhua and Landrace pigs

The intestinal microbiome is critically important in shaping a variety of host physiological responses. However, it remains elusive on how gut microbiota impacts overall growth and more specifically, adipogenesis. Using the pig as an animal model, we compared the differences in bacterial community s...

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Autores principales: Xiao, Yingping, Kong, Fanli, Xiang, Yun, Zhou, Weidong, Wang, Junjun, Yang, Hua, Zhang, Guolong, Zhao, Jiangchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899086/
https://www.ncbi.nlm.nih.gov/pubmed/29654314
http://dx.doi.org/10.1038/s41598-018-24289-z
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author Xiao, Yingping
Kong, Fanli
Xiang, Yun
Zhou, Weidong
Wang, Junjun
Yang, Hua
Zhang, Guolong
Zhao, Jiangchao
author_facet Xiao, Yingping
Kong, Fanli
Xiang, Yun
Zhou, Weidong
Wang, Junjun
Yang, Hua
Zhang, Guolong
Zhao, Jiangchao
author_sort Xiao, Yingping
collection PubMed
description The intestinal microbiome is critically important in shaping a variety of host physiological responses. However, it remains elusive on how gut microbiota impacts overall growth and more specifically, adipogenesis. Using the pig as an animal model, we compared the differences in bacterial community structure throughout the intestinal tract in two breeds (Landrace and Jinhua) of pigs with distinct phenotypes. The Landrace is a commercial purebred and the Jinhua is a Chinese indigenous, slow-growing breed with high propensity for fat deposition. Using 16S rRNA gene sequencing, we revealed that the bacterial communities are more diverse in the duodenum, jejunum, and cecum of Jinhua pigs than in those of Landrace pigs, whereas the ileal and colonic microbiota show a similar complexity between the two breeds. Furthermore, a number of bacterial taxa differentially exist in Jinhua and Landrace pigs throughout the entire intestinal tract, with the jejunal and ileal microbiome showing the greatest contrast. Functional prediction of the bacterial community suggested increased fatty acid biosynthesis in Jinghua pigs, which could partially explain their adiposity phenotype. Further studies are warranted to experimentally verify the relative contribution of each enriched bacterial species and their effect on adipogenesis and animal growth.
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spelling pubmed-58990862018-04-20 Comparative biogeography of the gut microbiome between Jinhua and Landrace pigs Xiao, Yingping Kong, Fanli Xiang, Yun Zhou, Weidong Wang, Junjun Yang, Hua Zhang, Guolong Zhao, Jiangchao Sci Rep Article The intestinal microbiome is critically important in shaping a variety of host physiological responses. However, it remains elusive on how gut microbiota impacts overall growth and more specifically, adipogenesis. Using the pig as an animal model, we compared the differences in bacterial community structure throughout the intestinal tract in two breeds (Landrace and Jinhua) of pigs with distinct phenotypes. The Landrace is a commercial purebred and the Jinhua is a Chinese indigenous, slow-growing breed with high propensity for fat deposition. Using 16S rRNA gene sequencing, we revealed that the bacterial communities are more diverse in the duodenum, jejunum, and cecum of Jinhua pigs than in those of Landrace pigs, whereas the ileal and colonic microbiota show a similar complexity between the two breeds. Furthermore, a number of bacterial taxa differentially exist in Jinhua and Landrace pigs throughout the entire intestinal tract, with the jejunal and ileal microbiome showing the greatest contrast. Functional prediction of the bacterial community suggested increased fatty acid biosynthesis in Jinghua pigs, which could partially explain their adiposity phenotype. Further studies are warranted to experimentally verify the relative contribution of each enriched bacterial species and their effect on adipogenesis and animal growth. Nature Publishing Group UK 2018-04-13 /pmc/articles/PMC5899086/ /pubmed/29654314 http://dx.doi.org/10.1038/s41598-018-24289-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Xiao, Yingping
Kong, Fanli
Xiang, Yun
Zhou, Weidong
Wang, Junjun
Yang, Hua
Zhang, Guolong
Zhao, Jiangchao
Comparative biogeography of the gut microbiome between Jinhua and Landrace pigs
title Comparative biogeography of the gut microbiome between Jinhua and Landrace pigs
title_full Comparative biogeography of the gut microbiome between Jinhua and Landrace pigs
title_fullStr Comparative biogeography of the gut microbiome between Jinhua and Landrace pigs
title_full_unstemmed Comparative biogeography of the gut microbiome between Jinhua and Landrace pigs
title_short Comparative biogeography of the gut microbiome between Jinhua and Landrace pigs
title_sort comparative biogeography of the gut microbiome between jinhua and landrace pigs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899086/
https://www.ncbi.nlm.nih.gov/pubmed/29654314
http://dx.doi.org/10.1038/s41598-018-24289-z
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