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Cell-free prediction of protein expression costs for growing cells

Translating heterologous proteins places significant burden on host cells, consuming expression resources leading to slower cell growth and productivity. Yet predicting the cost of protein production for any given gene is a major challenge, as multiple processes and factors combine to determine tran...

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Detalles Bibliográficos
Autores principales: Borkowski, Olivier, Bricio, Carlos, Murgiano, Michela, Rothschild-Mancinelli, Brooke, Stan, Guy-Bart, Ellis, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899134/
https://www.ncbi.nlm.nih.gov/pubmed/29654285
http://dx.doi.org/10.1038/s41467-018-03970-x