Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury

Damage of mitochondria in the initial period of tissue injury aggravates the severity of injury. Restoration of mitochondria dysfunction and mitochondrial-based therapeutics represent a potentially effective therapeutic strategy. Recently, mitochondrial transfer from stem cells has been demonstrated...

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Autores principales: Wang, Jingyu, Li, Heyangzi, Yao, Ying, Zhao, Tengfei, Chen, Ying-ying, Shen, Yue-liang, Wang, Lin-lin, Zhu, Yongjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899391/
https://www.ncbi.nlm.nih.gov/pubmed/29653590
http://dx.doi.org/10.1186/s13287-018-0832-2
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author Wang, Jingyu
Li, Heyangzi
Yao, Ying
Zhao, Tengfei
Chen, Ying-ying
Shen, Yue-liang
Wang, Lin-lin
Zhu, Yongjian
author_facet Wang, Jingyu
Li, Heyangzi
Yao, Ying
Zhao, Tengfei
Chen, Ying-ying
Shen, Yue-liang
Wang, Lin-lin
Zhu, Yongjian
author_sort Wang, Jingyu
collection PubMed
description Damage of mitochondria in the initial period of tissue injury aggravates the severity of injury. Restoration of mitochondria dysfunction and mitochondrial-based therapeutics represent a potentially effective therapeutic strategy. Recently, mitochondrial transfer from stem cells has been demonstrated to play a significant role in rescuing injured tissues. The possible mechanisms of mitochondria released from stem cells, the pathways of mitochondria transfer between the donor stem cells and recipient cells, and the internalization of mitochondria into recipient cells are discussed. Moreover, a novel strategy for tissue injury based on the concept of stem cell-derived mitochondrial transplantation is pointed out, and the advantages and challenges are summarized.
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spelling pubmed-58993912018-04-23 Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury Wang, Jingyu Li, Heyangzi Yao, Ying Zhao, Tengfei Chen, Ying-ying Shen, Yue-liang Wang, Lin-lin Zhu, Yongjian Stem Cell Res Ther Review Damage of mitochondria in the initial period of tissue injury aggravates the severity of injury. Restoration of mitochondria dysfunction and mitochondrial-based therapeutics represent a potentially effective therapeutic strategy. Recently, mitochondrial transfer from stem cells has been demonstrated to play a significant role in rescuing injured tissues. The possible mechanisms of mitochondria released from stem cells, the pathways of mitochondria transfer between the donor stem cells and recipient cells, and the internalization of mitochondria into recipient cells are discussed. Moreover, a novel strategy for tissue injury based on the concept of stem cell-derived mitochondrial transplantation is pointed out, and the advantages and challenges are summarized. BioMed Central 2018-04-13 /pmc/articles/PMC5899391/ /pubmed/29653590 http://dx.doi.org/10.1186/s13287-018-0832-2 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Wang, Jingyu
Li, Heyangzi
Yao, Ying
Zhao, Tengfei
Chen, Ying-ying
Shen, Yue-liang
Wang, Lin-lin
Zhu, Yongjian
Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury
title Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury
title_full Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury
title_fullStr Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury
title_full_unstemmed Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury
title_short Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury
title_sort stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899391/
https://www.ncbi.nlm.nih.gov/pubmed/29653590
http://dx.doi.org/10.1186/s13287-018-0832-2
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