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Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports

BACKGROUND: Amiodarone is a highly effective treatment for supraventricular and ventricular tachyarrhythmia; however, it could be associated with several serious adverse effects, including liver injury. CASE PRESENTATION: We report the clinical and histological features of two contrasting Japanese p...

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Autores principales: Tsuda, Toyonobu, Tada, Hayato, Tanaka, Yoshihiro, Nishida, Naoto, Yoshida, Taiji, Sawada, Takeshi, Sakata, Kenji, Hayashi, Kenshi, Kawashiri, Masa-aki, Oyama, Takeru, Sasaki, Motoko, Kurose, Nozomu, Yamagishi, Masakazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899395/
https://www.ncbi.nlm.nih.gov/pubmed/29653592
http://dx.doi.org/10.1186/s13256-018-1629-8
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author Tsuda, Toyonobu
Tada, Hayato
Tanaka, Yoshihiro
Nishida, Naoto
Yoshida, Taiji
Sawada, Takeshi
Sakata, Kenji
Hayashi, Kenshi
Kawashiri, Masa-aki
Oyama, Takeru
Sasaki, Motoko
Kurose, Nozomu
Yamagishi, Masakazu
author_facet Tsuda, Toyonobu
Tada, Hayato
Tanaka, Yoshihiro
Nishida, Naoto
Yoshida, Taiji
Sawada, Takeshi
Sakata, Kenji
Hayashi, Kenshi
Kawashiri, Masa-aki
Oyama, Takeru
Sasaki, Motoko
Kurose, Nozomu
Yamagishi, Masakazu
author_sort Tsuda, Toyonobu
collection PubMed
description BACKGROUND: Amiodarone is a highly effective treatment for supraventricular and ventricular tachyarrhythmia; however, it could be associated with several serious adverse effects, including liver injury. CASE PRESENTATION: We report the clinical and histological features of two contrasting Japanese patients with amiodarone-induced reversible and irreversible hepatotoxicity. One patient with amiodarone-induced irreversible hepatotoxicity showed liver cirrhosis during treatment with amiodarone and died of hepatic failure; the other patient, who had reversible hepatotoxicity, showed a reversible course of liver function and imaging after discontinuation of amiodarone. CONCLUSIONS: We emphasize the importance of close monitoring of liver enzymes and evaluation of liver computed tomographic imaging as well as liver biopsy during treatment with amiodarone, and discontinuation should be considered when amiodarone-induced hepatotoxicity is suspected.
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spelling pubmed-58993952018-04-23 Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports Tsuda, Toyonobu Tada, Hayato Tanaka, Yoshihiro Nishida, Naoto Yoshida, Taiji Sawada, Takeshi Sakata, Kenji Hayashi, Kenshi Kawashiri, Masa-aki Oyama, Takeru Sasaki, Motoko Kurose, Nozomu Yamagishi, Masakazu J Med Case Rep Case Report BACKGROUND: Amiodarone is a highly effective treatment for supraventricular and ventricular tachyarrhythmia; however, it could be associated with several serious adverse effects, including liver injury. CASE PRESENTATION: We report the clinical and histological features of two contrasting Japanese patients with amiodarone-induced reversible and irreversible hepatotoxicity. One patient with amiodarone-induced irreversible hepatotoxicity showed liver cirrhosis during treatment with amiodarone and died of hepatic failure; the other patient, who had reversible hepatotoxicity, showed a reversible course of liver function and imaging after discontinuation of amiodarone. CONCLUSIONS: We emphasize the importance of close monitoring of liver enzymes and evaluation of liver computed tomographic imaging as well as liver biopsy during treatment with amiodarone, and discontinuation should be considered when amiodarone-induced hepatotoxicity is suspected. BioMed Central 2018-04-14 /pmc/articles/PMC5899395/ /pubmed/29653592 http://dx.doi.org/10.1186/s13256-018-1629-8 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Tsuda, Toyonobu
Tada, Hayato
Tanaka, Yoshihiro
Nishida, Naoto
Yoshida, Taiji
Sawada, Takeshi
Sakata, Kenji
Hayashi, Kenshi
Kawashiri, Masa-aki
Oyama, Takeru
Sasaki, Motoko
Kurose, Nozomu
Yamagishi, Masakazu
Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports
title Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports
title_full Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports
title_fullStr Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports
title_full_unstemmed Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports
title_short Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports
title_sort amiodarone-induced reversible and irreversible hepatotoxicity: two case reports
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899395/
https://www.ncbi.nlm.nih.gov/pubmed/29653592
http://dx.doi.org/10.1186/s13256-018-1629-8
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