Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases

Interleukin-37 (IL-37) is an IL-1 family cytokine discovered in recent years and has 5 different isoforms. As an immunosuppressive factor, IL-37 can suppress excessive immune response. IL-37 plays a role in protecting the body against endotoxin shock, ischemia-reperfusion injury, autoimmune diseases...

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Detalles Bibliográficos
Autores principales: Jia, Hailin, Liu, Jing, Han, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899839/
https://www.ncbi.nlm.nih.gov/pubmed/29805973
http://dx.doi.org/10.1155/2018/3058640
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author Jia, Hailin
Liu, Jing
Han, Bo
author_facet Jia, Hailin
Liu, Jing
Han, Bo
author_sort Jia, Hailin
collection PubMed
description Interleukin-37 (IL-37) is an IL-1 family cytokine discovered in recent years and has 5 different isoforms. As an immunosuppressive factor, IL-37 can suppress excessive immune response. IL-37 plays a role in protecting the body against endotoxin shock, ischemia-reperfusion injury, autoimmune diseases, and cardiovascular diseases. In addition, IL-37 has a potential antitumor effect. IL-37 and its receptors may serve as novel targets for the study, diagnosis, and treatment of immune-related diseases and tumors.
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spelling pubmed-58998392018-05-27 Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases Jia, Hailin Liu, Jing Han, Bo Biomed Res Int Review Article Interleukin-37 (IL-37) is an IL-1 family cytokine discovered in recent years and has 5 different isoforms. As an immunosuppressive factor, IL-37 can suppress excessive immune response. IL-37 plays a role in protecting the body against endotoxin shock, ischemia-reperfusion injury, autoimmune diseases, and cardiovascular diseases. In addition, IL-37 has a potential antitumor effect. IL-37 and its receptors may serve as novel targets for the study, diagnosis, and treatment of immune-related diseases and tumors. Hindawi 2018-04-01 /pmc/articles/PMC5899839/ /pubmed/29805973 http://dx.doi.org/10.1155/2018/3058640 Text en Copyright © 2018 Hailin Jia et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jia, Hailin
Liu, Jing
Han, Bo
Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases
title Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases
title_full Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases
title_fullStr Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases
title_full_unstemmed Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases
title_short Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases
title_sort reviews of interleukin-37: functions, receptors, and roles in diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899839/
https://www.ncbi.nlm.nih.gov/pubmed/29805973
http://dx.doi.org/10.1155/2018/3058640
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