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Factors Influencing Hemoglobin Variability and Its Association with Mortality in Hemodialysis Patients
PURPOSE: We aimed to investigate the factors influencing hemoglobin variability with inflammatory and nutritional parameters and its associations with all-cause mortality among hemodialysis patients. METHODS: One hundred and sixty-nine patients during the entire 12 months were enrolled into the stud...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899870/ https://www.ncbi.nlm.nih.gov/pubmed/29805324 http://dx.doi.org/10.1155/2018/8065691 |
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author | Bal, Zeynep Demirci, Bahar Gurlek Karakose, Suleyman Tutal, Emre Erkmen Uyar, Mehtap Acar, Nurhan Ozdemir Sezer, Siren |
author_facet | Bal, Zeynep Demirci, Bahar Gurlek Karakose, Suleyman Tutal, Emre Erkmen Uyar, Mehtap Acar, Nurhan Ozdemir Sezer, Siren |
author_sort | Bal, Zeynep |
collection | PubMed |
description | PURPOSE: We aimed to investigate the factors influencing hemoglobin variability with inflammatory and nutritional parameters and its associations with all-cause mortality among hemodialysis patients. METHODS: One hundred and sixty-nine patients during the entire 12 months were enrolled into the study. Fasting plasma glucose, creatinine, calcium, phosphorus, alkaline phosphatase, parathyroid hormone (PTH), C-reactive protein (CRP), serum iron, serum iron-binding capacity, and transferrin saturation were analyzed. We defined six groups: low, target range, high, low-amplitude fluctuation with low hemoglobin levels, low-amplitude fluctuation with high hemoglobin levels, and high-amplitude fluctuation. Body mass index (BMI), malnutrition-inflammation score (MIS), and Charlson Comorbidity Index were evaluated. RESULTS: Hemoglobin variability was significantly correlated with age, platelet count, and number of hospitalization instances and inversely correlated with erythropoietin dose per body surface area. The coefficient of variation of hemoglobin showed a correlation with MIS and ferritin. The absolute level of hemoglobin showed a negative correlation between PTH, CRP, MIS, number of hospitalization instances and a positive correlation with albumin and BMI. High, low, and target-range groups showed survival advantage compared to the other three groups. In regression analysis, age, CRP levels, MIS, and BMI were the predictors of mortality. CONCLUSION: Inflammation and duration of anemia were the major predictors of hemoglobin variability. High-amplitude fluctuation predicts high mortality; on the contrary low-amplitude fluctuations is related to better survival. MIS was independently associated with mortality. This trial is registered with NCT03454906. |
format | Online Article Text |
id | pubmed-5899870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58998702018-05-27 Factors Influencing Hemoglobin Variability and Its Association with Mortality in Hemodialysis Patients Bal, Zeynep Demirci, Bahar Gurlek Karakose, Suleyman Tutal, Emre Erkmen Uyar, Mehtap Acar, Nurhan Ozdemir Sezer, Siren ScientificWorldJournal Clinical Study PURPOSE: We aimed to investigate the factors influencing hemoglobin variability with inflammatory and nutritional parameters and its associations with all-cause mortality among hemodialysis patients. METHODS: One hundred and sixty-nine patients during the entire 12 months were enrolled into the study. Fasting plasma glucose, creatinine, calcium, phosphorus, alkaline phosphatase, parathyroid hormone (PTH), C-reactive protein (CRP), serum iron, serum iron-binding capacity, and transferrin saturation were analyzed. We defined six groups: low, target range, high, low-amplitude fluctuation with low hemoglobin levels, low-amplitude fluctuation with high hemoglobin levels, and high-amplitude fluctuation. Body mass index (BMI), malnutrition-inflammation score (MIS), and Charlson Comorbidity Index were evaluated. RESULTS: Hemoglobin variability was significantly correlated with age, platelet count, and number of hospitalization instances and inversely correlated with erythropoietin dose per body surface area. The coefficient of variation of hemoglobin showed a correlation with MIS and ferritin. The absolute level of hemoglobin showed a negative correlation between PTH, CRP, MIS, number of hospitalization instances and a positive correlation with albumin and BMI. High, low, and target-range groups showed survival advantage compared to the other three groups. In regression analysis, age, CRP levels, MIS, and BMI were the predictors of mortality. CONCLUSION: Inflammation and duration of anemia were the major predictors of hemoglobin variability. High-amplitude fluctuation predicts high mortality; on the contrary low-amplitude fluctuations is related to better survival. MIS was independently associated with mortality. This trial is registered with NCT03454906. Hindawi 2018-04-01 /pmc/articles/PMC5899870/ /pubmed/29805324 http://dx.doi.org/10.1155/2018/8065691 Text en Copyright © 2018 Zeynep Bal et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Bal, Zeynep Demirci, Bahar Gurlek Karakose, Suleyman Tutal, Emre Erkmen Uyar, Mehtap Acar, Nurhan Ozdemir Sezer, Siren Factors Influencing Hemoglobin Variability and Its Association with Mortality in Hemodialysis Patients |
title | Factors Influencing Hemoglobin Variability and Its Association with Mortality in Hemodialysis Patients |
title_full | Factors Influencing Hemoglobin Variability and Its Association with Mortality in Hemodialysis Patients |
title_fullStr | Factors Influencing Hemoglobin Variability and Its Association with Mortality in Hemodialysis Patients |
title_full_unstemmed | Factors Influencing Hemoglobin Variability and Its Association with Mortality in Hemodialysis Patients |
title_short | Factors Influencing Hemoglobin Variability and Its Association with Mortality in Hemodialysis Patients |
title_sort | factors influencing hemoglobin variability and its association with mortality in hemodialysis patients |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899870/ https://www.ncbi.nlm.nih.gov/pubmed/29805324 http://dx.doi.org/10.1155/2018/8065691 |
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