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Reproducible and efficient generation of functionally active neurons from human hiPSCs for preclinical disease modeling

The use of human induced pluripotent stem cell (hiPSC)-derived neuronal cultures to study the mechanisms of neurological disorders is often limited by low efficiency and high variability in differentiation of functional neurons. Here we compare the functional properties of neurons in cultures prepar...

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Detalles Bibliográficos
Autores principales:	Xie, Yunyao, Schutte, Ryan J., Ng, Nathan N., Ess, Kevin C., Schwartz, Philip H., O’Dowd, Diane K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899925/ https://www.ncbi.nlm.nih.gov/pubmed/29272856 http://dx.doi.org/10.1016/j.scr.2017.12.003

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