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Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells

Diphosphoinositol pentakisphosphate (IP(7)) is critical for the exocytotic capacity of the pancreatic β-cell, but its regulation by the primary instigator of β-cell exocytosis, glucose, is unknown. The high K(m) for ATP of the IP(7)-generating enzymes, the inositol hexakisphosphate kinases (IP6K1 an...

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Detalles Bibliográficos
Autores principales:	Rajasekaran, Subu Surendran, Kim, Jaeyoon, Gaboardi, Gian-Carlo, Gromada, Jesper, Shears, Stephen B., dos Santos, Karen Tiago, Nolasco, Eduardo Lima, Ferreira, Sabrina de Souza, Illies, Christopher, Köhler, Martin, Gu, Chunfang, Ryu, Sung Ho, Martins, Joilson O., Darè, Elisabetta, Barker, Christopher J., Berggren, Per-Olof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Ltd 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899964/ https://www.ncbi.nlm.nih.gov/pubmed/29522819 http://dx.doi.org/10.1016/j.cellsig.2018.03.001

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