Cargando…

Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice

It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5, slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the metabolic profiles of urine and plasma from male,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Varshavi, Dorsa, Scott, Flora H., Varshavi, Dorna, Veeravalli, Sunil, Phillips, Ian R., Veselkov, Kirill, Strittmatter, Nicole, Takats, Zoltan, Shephard, Elizabeth A., Everett, Jeremy R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900034/ https://www.ncbi.nlm.nih.gov/pubmed/29686991 http://dx.doi.org/10.3389/fmolb.2018.00028

Ejemplares similares

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing
por: Gonzalez Malagon, Sandra G., et al.
Publicado: (2015)

Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5 (−/−) mice, decreases plasma cholesterol and epididymal fat deposition
por: Veeravalli, Sunil, et al.
Publicado: (2022)

Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines
por: Varshavi, Dorna, et al.
Publicado: (2020)

Metabonomics study of the effects of single copy mutant KRAS in the presence or absence of WT allele using human HCT116 isogenic cell lines
por: Varshavi, Dorna, et al.
Publicado: (2021)

Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria
por: Scott, Flora, et al.
Publicado: (2017)

Metabolomic and transcriptomic analyses of Fmo5(-/)(- )mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism
por: Phillips, Ian R., et al.
Publicado: (2023)

A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments
por: Dona, Anthony C., et al.
Publicado: (2016)

Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
por: El-Serafi, Ibrahim, et al.
Publicado: (2017)

Correction: Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
Publicado: (2017)

Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease
por: Fennema, Diede, et al.
Publicado: (2016)

Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians
por: Dolan, Ciara, et al.
Publicado: (2005)

Effect of Flavin-Containing Monooxygenase Genotype, Mouse Strain, and Gender on Trimethylamine N-oxide Production, Plasma Cholesterol Concentration, and an Index of Atherosclerosis
por: Veeravalli, Sunil, et al.
Publicado: (2018)

Flavin-Containing Monooxygenase 3 (FMO3) Is Critical for Dioxin-Induced Reorganization of the Gut Microbiome and Host Insulin Sensitivity
por: Massey, William, et al.
Publicado: (2022)

Analysis of six novel flavin-containing monooxygenase 3 (FMO3) gene variants found in a Japanese population suffering from trimethylaminuria
por: Shimizu, Makiko, et al.
Publicado: (2015)

Novel flavin-containing monooxygenase protein FMO1 interacts with CAT2 to negatively regulate drought tolerance through ROS homeostasis and ABA signaling pathway in tomato
por: Wang, Lulu, et al.
Publicado: (2023)

Chopping and Changing: the Evolution of the Flavin-dependent Monooxygenases
por: Mascotti, Maria Laura, et al.
Publicado: (2016)

Evolution of enzyme functionality in the flavin-containing monooxygenases
por: Bailleul, Gautier, et al.
Publicado: (2023)

The Origin and Evolution of Baeyer—Villiger Monooxygenases (BVMOs): An Ancestral Family of Flavin Monooxygenases
por: Mascotti, Maria Laura, et al.
Publicado: (2015)

Metabolism and Pharmacokinetics of the Anti-Tuberculosis Drug Ethionamide in a Flavin-Containing Monooxygenase Null Mouse
por: Palmer, Amy L., et al.
Publicado: (2012)

CCR5 knockout suppresses experimental autoimmune encephalomyelitis in C57BL/6 mice
por: Gu, Sun Mi, et al.
Publicado: (2016)

Flavin-Containing Monooxygenases Are Conserved Regulators of Stress Resistance and Metabolism
por: Huang, Shijiao, et al.
Publicado: (2021)

QM/MM Modeling of the Flavin Functionalization in the RutA Monooxygenase
por: Grigorenko, Bella, et al.
Publicado: (2023)

Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis
por: Wang, Qian, et al.
Publicado: (2023)

Two Novel Flavin-Containing Monooxygenases Involved in Biosynthesis of Aliphatic Glucosinolates
por: Kong, Wenwen, et al.
Publicado: (2016)

Flavin Conjugated Polydopamine Nanoparticles Displaying Light-Driven Monooxygenase Activity
por: Crocker, Leander, et al.
Publicado: (2019)

Use of Flavin-Containing Monooxygenases for Conversion of Trimethylamine in Salmon Protein Hydrolysates
por: Goris, Marianne, et al.
Publicado: (2020)

Metabolic Regulation of Longevity by One-Carbon Metabolism and Flavin-Containing Monooxygenase
por: Choi, Christopher, et al.
Publicado: (2020)

Properties and Mechanisms of Flavin-Dependent Monooxygenases and Their Applications in Natural Product Synthesis
por: Deng, Yaming, et al.
Publicado: (2022)

Engineered Bacterial Flavin‐Dependent Monooxygenases for the Regiospecific Hydroxylation of Polycyclic Phenols
por: Herrmann, Susann, et al.
Publicado: (2022)

A flavin-monooxygenase catalyzing oxepinone formation and the complete biosynthesis of vibralactone
por: Feng, Ke-Na, et al.
Publicado: (2023)

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
por: Miao, Ji, et al.
Publicado: (2015)

C. elegans flavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress
por: Hirani, Nisha, et al.
Publicado: (2016)

C. elegans flavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress
por: Hirani, Nisha, et al.
Publicado: (2016)

Oxidative dehalogenation and denitration by a flavin-dependent monooxygenase is controlled by substrate deprotonation
por: Pimviriyakul, Panu, et al.
Publicado: (2018)

FLAVIN-CONTAINING MONOOXYGENASES (FMOS): LONGEVITY-PROMOTING ENZYMES OR ATHEROSCLEROSIS RISK FACTOR?
por: Rossner, Ryan J, et al.
Publicado: (2019)

Deciphering the evolution of flavin-dependent monooxygenase stereoselectivity using ancestral sequence reconstruction
por: Chiang, Chang-Hwa, et al.
Publicado: (2023)

A Cold-Active Flavin-Dependent Monooxygenase from Janthinobacterium svalbardensis Unlocks Applications of Baeyer–Villiger Monooxygenases at Low Temperature
por: Chánique, Andrea M., et al.
Publicado: (2023)

HMDB 5.0: the Human Metabolome Database for 2022
por: Wishart, David S, et al.
Publicado: (2021)

Effect of Human Flavin-Containing Monooxygenase 3 Polymorphism on the Metabolism of Aurora Kinase Inhibitors
por: Catucci, Gianluca, et al.
Publicado: (2013)

How pH Modulates the Reactivity and Selectivity of a Siderophore-Associated Flavin Monooxygenase
por: Frederick, Rosanne E., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_v16ltvascp9v1eetg2tapq6q6g