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Height outcome of the recombinant human growth hormone treatment in Turner syndrome: a meta-analysis

OBJECTIVE: This study sought to determine the effect of the recombinant human growth hormone (rhGH) treatment of Turner syndrome (TS) on height outcome. METHODS: We searched in MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews. A literatur...

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Detalles Bibliográficos
Autores principales: Li, Ping, Cheng, Fei, Xiu, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900457/
https://www.ncbi.nlm.nih.gov/pubmed/29581156
http://dx.doi.org/10.1530/EC-18-0115
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author Li, Ping
Cheng, Fei
Xiu, Lei
author_facet Li, Ping
Cheng, Fei
Xiu, Lei
author_sort Li, Ping
collection PubMed
description OBJECTIVE: This study sought to determine the effect of the recombinant human growth hormone (rhGH) treatment of Turner syndrome (TS) on height outcome. METHODS: We searched in MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews. A literature search identified 640 records. After screening and full-text assessment, 11 records were included in the systematic review. Methodological quality was assessed using the Cochrane Risk of Bias tool. RevMan 5.3 software was used for meta-analysis. We also assessed the quality of evidence with the GRADE system. RESULTS: Compared with controls, rhGH therapy led to increased final height (MD = 7.22 cm, 95% CI 5.27–9.18, P < 0.001, I2 = 4%; P = 0.18), height standard deviation (HtSDS) (SMD = 1.22, 95% CI 0.88–1.56, P < 0.001, I2 = 49%; P = 0.14) and height velocity (HV) (MD 2.68 cm/year; 95% CI 2.34, 3.02; P < 0.001, I2 = 0%; P = 0.72). There was a small increase in bone age (SMD 0.32 years; 95% CI 0.1, 0.54; P = 0.004, I2 = 73%; P = 0.02) after rhGH therapy for 12 months. What is more, the rhGH/oxandrolone combination therapy suggested greater final height (MD 2.46 cm; 95% CI 0.73, 4.18; P = 0.005, I2 = 32%; P = 0.22), increase and faster HV (SMD 1.67 cm/year; 95% CI 1.03, 2.31; P < 0.03, I2 = 80%; P < 0.001), with no significant increase in HtSDS and bone maturation compared with rhGH therapy alone. CONCLUSIONS: For TS patients, rhGH alone or with concomitant use of oxandrolone treatment had advantages on final height.
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spelling pubmed-59004572018-04-19 Height outcome of the recombinant human growth hormone treatment in Turner syndrome: a meta-analysis Li, Ping Cheng, Fei Xiu, Lei Endocr Connect Research OBJECTIVE: This study sought to determine the effect of the recombinant human growth hormone (rhGH) treatment of Turner syndrome (TS) on height outcome. METHODS: We searched in MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews. A literature search identified 640 records. After screening and full-text assessment, 11 records were included in the systematic review. Methodological quality was assessed using the Cochrane Risk of Bias tool. RevMan 5.3 software was used for meta-analysis. We also assessed the quality of evidence with the GRADE system. RESULTS: Compared with controls, rhGH therapy led to increased final height (MD = 7.22 cm, 95% CI 5.27–9.18, P < 0.001, I2 = 4%; P = 0.18), height standard deviation (HtSDS) (SMD = 1.22, 95% CI 0.88–1.56, P < 0.001, I2 = 49%; P = 0.14) and height velocity (HV) (MD 2.68 cm/year; 95% CI 2.34, 3.02; P < 0.001, I2 = 0%; P = 0.72). There was a small increase in bone age (SMD 0.32 years; 95% CI 0.1, 0.54; P = 0.004, I2 = 73%; P = 0.02) after rhGH therapy for 12 months. What is more, the rhGH/oxandrolone combination therapy suggested greater final height (MD 2.46 cm; 95% CI 0.73, 4.18; P = 0.005, I2 = 32%; P = 0.22), increase and faster HV (SMD 1.67 cm/year; 95% CI 1.03, 2.31; P < 0.03, I2 = 80%; P < 0.001), with no significant increase in HtSDS and bone maturation compared with rhGH therapy alone. CONCLUSIONS: For TS patients, rhGH alone or with concomitant use of oxandrolone treatment had advantages on final height. Bioscientifica Ltd 2018-03-26 /pmc/articles/PMC5900457/ /pubmed/29581156 http://dx.doi.org/10.1530/EC-18-0115 Text en © 2018 The authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Li, Ping
Cheng, Fei
Xiu, Lei
Height outcome of the recombinant human growth hormone treatment in Turner syndrome: a meta-analysis
title Height outcome of the recombinant human growth hormone treatment in Turner syndrome: a meta-analysis
title_full Height outcome of the recombinant human growth hormone treatment in Turner syndrome: a meta-analysis
title_fullStr Height outcome of the recombinant human growth hormone treatment in Turner syndrome: a meta-analysis
title_full_unstemmed Height outcome of the recombinant human growth hormone treatment in Turner syndrome: a meta-analysis
title_short Height outcome of the recombinant human growth hormone treatment in Turner syndrome: a meta-analysis
title_sort height outcome of the recombinant human growth hormone treatment in turner syndrome: a meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900457/
https://www.ncbi.nlm.nih.gov/pubmed/29581156
http://dx.doi.org/10.1530/EC-18-0115
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