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SNARE complex in axonal guidance and neuroregeneration
Through complex mechanisms that guide axons to the appropriate routes towards their targets, axonal growth and guidance lead to neuronal system formation. These mechanisms establish the synaptic circuitry necessary for the optimal performance of the nervous system in all organisms. Damage to these n...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900491/ https://www.ncbi.nlm.nih.gov/pubmed/29623913 http://dx.doi.org/10.4103/1673-5374.228710 |
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author | Ulloa, Fausto Cotrufo, Tiziana Ricolo, Delia Soriano, Eduardo Araújo, Sofia J. |
author_facet | Ulloa, Fausto Cotrufo, Tiziana Ricolo, Delia Soriano, Eduardo Araújo, Sofia J. |
author_sort | Ulloa, Fausto |
collection | PubMed |
description | Through complex mechanisms that guide axons to the appropriate routes towards their targets, axonal growth and guidance lead to neuronal system formation. These mechanisms establish the synaptic circuitry necessary for the optimal performance of the nervous system in all organisms. Damage to these networks can be repaired by neuroregenerative processes which in turn can re-establish synapses between injured axons and postsynaptic terminals. Both axonal growth and guidance and the neuroregenerative response rely on correct axonal growth and growth cone responses to guidance cues as well as correct synapses with appropriate targets. With this in mind, parallels can be drawn between axonal regeneration and processes occurring during embryonic nervous system development. However, when studying parallels between axonal development and regeneration many questions still arise; mainly, how do axons grow and synapse with their targets and how do they repair their membranes, grow and orchestrate regenerative responses after injury. Major players in the cellular and molecular processes that lead to growth cone development and movement during embryonic development are the Soluble N-ethylamaleimide Sensitive Factor (NSF) Attachment Protein Receptor (SNARE) proteins, which have been shown to be involved in axonal growth and guidance. Their involvement in axonal growth, guidance and neuroregeneration is of foremost importance, due to their roles in vesicle and membrane trafficking events. Here, we review the recent literature on the involvement of SNARE proteins in axonal growth and guidance during embryonic development and neuroregeneration. |
format | Online Article Text |
id | pubmed-5900491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59004912018-04-24 SNARE complex in axonal guidance and neuroregeneration Ulloa, Fausto Cotrufo, Tiziana Ricolo, Delia Soriano, Eduardo Araújo, Sofia J. Neural Regen Res Invited Review Through complex mechanisms that guide axons to the appropriate routes towards their targets, axonal growth and guidance lead to neuronal system formation. These mechanisms establish the synaptic circuitry necessary for the optimal performance of the nervous system in all organisms. Damage to these networks can be repaired by neuroregenerative processes which in turn can re-establish synapses between injured axons and postsynaptic terminals. Both axonal growth and guidance and the neuroregenerative response rely on correct axonal growth and growth cone responses to guidance cues as well as correct synapses with appropriate targets. With this in mind, parallels can be drawn between axonal regeneration and processes occurring during embryonic nervous system development. However, when studying parallels between axonal development and regeneration many questions still arise; mainly, how do axons grow and synapse with their targets and how do they repair their membranes, grow and orchestrate regenerative responses after injury. Major players in the cellular and molecular processes that lead to growth cone development and movement during embryonic development are the Soluble N-ethylamaleimide Sensitive Factor (NSF) Attachment Protein Receptor (SNARE) proteins, which have been shown to be involved in axonal growth and guidance. Their involvement in axonal growth, guidance and neuroregeneration is of foremost importance, due to their roles in vesicle and membrane trafficking events. Here, we review the recent literature on the involvement of SNARE proteins in axonal growth and guidance during embryonic development and neuroregeneration. Medknow Publications & Media Pvt Ltd 2018-03 /pmc/articles/PMC5900491/ /pubmed/29623913 http://dx.doi.org/10.4103/1673-5374.228710 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Invited Review Ulloa, Fausto Cotrufo, Tiziana Ricolo, Delia Soriano, Eduardo Araújo, Sofia J. SNARE complex in axonal guidance and neuroregeneration |
title | SNARE complex in axonal guidance and neuroregeneration |
title_full | SNARE complex in axonal guidance and neuroregeneration |
title_fullStr | SNARE complex in axonal guidance and neuroregeneration |
title_full_unstemmed | SNARE complex in axonal guidance and neuroregeneration |
title_short | SNARE complex in axonal guidance and neuroregeneration |
title_sort | snare complex in axonal guidance and neuroregeneration |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900491/ https://www.ncbi.nlm.nih.gov/pubmed/29623913 http://dx.doi.org/10.4103/1673-5374.228710 |
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