Cargando…

Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing

Genome editing has proven to be highly potent in the generation of functional gene knockouts in dividing cells. In the CNS however, efficient technologies to repair sequences are yet to materialize. Reprogramming on the mRNA level is an attractive alternative as it provides means to perform in situ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Davidsson, Marcus, Díaz-Fernández, Paula, Torroba, Marcos, Schwich, Oliver D., Aldrin-Kirk, Patrick, Quintino, Luis, Heuer, Andreas, Wang, Gang, Lundberg, Cecilia, Björklund, Tomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900565/ https://www.ncbi.nlm.nih.gov/pubmed/29386333 http://dx.doi.org/10.1261/rna.063925.117

Ejemplares similares

A novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing
por: Davidsson, Marcus, et al.
Publicado: (2016)

A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism
por: Davidsson, Marcus, et al.
Publicado: (2019)

Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons
por: Aldrin-Kirk, Patrick, et al.
Publicado: (2014)

Next-Generation Gene Therapy for Parkinson’s Disease Using Engineered Viral Vectors
por: Björklund, Tomas, et al.
Publicado: (2021)

A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants
por: Aldrin-Kirk, Patrick, et al.
Publicado: (2021)

Destabilizing Domains Enable Long-Term and Inert Regulation of GDNF Expression in the Brain
por: Quintino, Luis, et al.
Publicado: (2018)

Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo
por: Rájová, Jana, et al.
Publicado: (2023)

Trans-spliced mRNA products produced from circRNA expression vectors
por: Chu, Jennifer, et al.
Publicado: (2021)

Small scale adeno-associated virus-vector production for preclinical gene delivery based on chloroform precipitation
por: Davidsson, Marcus, et al.
Publicado: (2021)

mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapy
por: Riedmayr, Lisa Maria, et al.
Publicado: (2023)

DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor
por: Aldrin-Kirk, Patrick, et al.
Publicado: (2016)

mRNA trans‐splicing in gene therapy for genetic diseases
por: Berger, Adeline, et al.
Publicado: (2016)

AAV-vectored base editor trans-splicing delivers dystrophin repair
por: Li, Zhen, et al.
Publicado: (2023)

A comparison of AAV-vector production methods for gene therapy and preclinical assessment
por: Davidsson, Marcus, et al.
Publicado: (2020)

Reprogramming the Dynamin 2 mRNA by Spliceosome-mediated RNA Trans-splicing
por: Trochet, Delphine, et al.
Publicado: (2016)

A trans-spliced leader sequence on actin mRNA in C. elegans
por: Krause, Michael, et al.
Publicado: (1987)

Spliceosome-Mediated Pre-mRNA trans-Splicing Can Repair CEP290 mRNA
por: Dooley, Scott J., et al.
Publicado: (2018)

Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling
por: Avallone, Martino, et al.
Publicado: (2023)

Development of a Single Vector System that Enhances Trans-Splicing of SMN2 Transcripts
por: Coady, Tristan H., et al.
Publicado: (2008)

Genomic overview of mRNA 5′-leader trans-splicing in the ascidian Ciona intestinalis
por: Satou, Yutaka, et al.
Publicado: (2006)

BEST: Barcode Enabled Sequencing of Tetrads
por: Scott, Adrian C., et al.
Publicado: (2014)

Evidence for Trans splicing in trypanosomes
por: Sutton, Richard E., et al.
Publicado: (1986)

Spliced leader RNA trans-splicing discovered in copepods
por: Yang, Feifei, et al.
Publicado: (2015)

Trans-splicing of pre-mRNA is predicted to occur in a wide range of organisms including vertebrates.
por: Dandekar, T, et al.
Publicado: (1990)

Repair of Mybpc3 mRNA by 5′-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy
por: Mearini, Giulia, et al.
Publicado: (2013)

Efficient system for upstream mRNA trans-splicing to generate covalent, head-to-tail, protein multimers
por: Mitsuhashi, Hiroaki, et al.
Publicado: (2019)

Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development
por: Tang, Sze Jing, et al.
Publicado: (2020)

Landscape of the spliced leader trans-splicing mechanism in Schistosoma mansoni
por: Boroni, Mariana, et al.
Publicado: (2018)

Trans splicing in trypanosomes — archaism or adaptation?
por: Laird, Peter W.
Publicado: (1989)

Homologous SV40 RNA trans-splicing: Special case or prime example of viral RNA trans-splicing?
por: Poddar, Sushmita, et al.
Publicado: (2014)

DNA barcodes enable higher taxonomic assignments in the Acari
por: Young, Monica R., et al.
Publicado: (2021)

Genomic and Transcriptomic Analysis Reveals Spliced Leader Trans-Splicing in Cryptomonads
por: Roy, Scott William
Publicado: (2017)

Prediction of alternative pre-mRNA splicing outcomes
por: Najjar, Rayan, et al.
Publicado: (2023)

A computational investigation of kinetoplastid trans-splicing
por: Gopal, Shuba, et al.
Publicado: (2005)

Evolutionary Insights into RNA trans-Splicing in Vertebrates
por: Lei, Quan, et al.
Publicado: (2016)

Extending AAV Packaging Cargo through Dual Co-Transduction: Efficient Protein Trans-Splicing at Low Vector Doses
por: Ferreira, Mariana V., et al.
Publicado: (2023)

Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors
por: Kretova, Miroslava, et al.
Publicado: (2023)

The Trypanosoma brucei RNA-binding protein DRBD18 ensures correct mRNA trans splicing and polyadenylation patterns
por: Bishola Tshitenge, Tania, et al.
Publicado: (2022)

Repair of Rhodopsin mRNA by Spliceosome-Mediated RNA Trans-Splicing: A New Approach for Autosomal Dominant Retinitis Pigmentosa
por: Berger, Adeline, et al.
Publicado: (2015)

Operon Conservation and the Evolution of trans-Splicing in the Phylum Nematoda
por: Guiliano, David B, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_t6tq6db4k5pi4n0marlcqn3m9i