Oncoprotein AEG-1 is an endoplasmic reticulum RNA-binding protein whose interactome is enriched in organelle resident protein-encoding mRNAs

Astrocyte elevated gene-1 (AEG-1), an oncogene whose overexpression promotes tumor cell proliferation, angiogenesis, invasion, and enhanced chemoresistance, is thought to function primarily as a scaffolding protein, regulating PI3K/Akt and Wnt/β-catenin signaling pathways. Here we report that AEG-1...

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Detalles Bibliográficos
Autores principales: Hsu, Jack C.-C., Reid, David W., Hoffman, Alyson M., Sarkar, Devanand, Nicchitta, Christopher V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900566/
https://www.ncbi.nlm.nih.gov/pubmed/29438049
http://dx.doi.org/10.1261/rna.063313.117

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