Cargando…

A day in the life of chromatin: how enhancer–promoter loops shape daily behavior

Each spring, we get out of bed 1 h ahead of our biological wake-up time due to the misalignment of internal clocks with the light–dark cycle. Genetic discoveries revealed that clock genes encode transcription factors that are expressed throughout many tissues, yet a gap has remained in understanding...

Descripción completa

Detalles Bibliográficos
Autores principales: Weidemann, Benjamin J., Ramsey, Kathryn Moynihan, Bass, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900705/
https://www.ncbi.nlm.nih.gov/pubmed/29593064
http://dx.doi.org/10.1101/gad.314187.118
_version_ 1783314466739322880
author Weidemann, Benjamin J.
Ramsey, Kathryn Moynihan
Bass, Joseph
author_facet Weidemann, Benjamin J.
Ramsey, Kathryn Moynihan
Bass, Joseph
author_sort Weidemann, Benjamin J.
collection PubMed
description Each spring, we get out of bed 1 h ahead of our biological wake-up time due to the misalignment of internal clocks with the light–dark cycle. Genetic discoveries revealed that clock genes encode transcription factors that are expressed throughout many tissues, yet a gap has remained in understanding the temporal dynamics of transcription. Two groups now apply circular chromosome conformation capture and high-throughput sequencing to dissect how “time of day”-dependent changes in chromatin drive core clock oscillations. A surprise is the finding that disruption of enhancer–promoter contacts within chromatin leads to an advance in the “wake-up” time of mice. Furthermore, the assembly of transcriptionally active domains of chromatin requires the ordered recruitment of core clock transcription factors each day. These studies show that waking up involves highly dynamic changes in the three-dimensional positioning of genes within the cell.
format Online
Article
Text
id pubmed-5900705
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Cold Spring Harbor Laboratory Press
record_format MEDLINE/PubMed
spelling pubmed-59007052018-05-04 A day in the life of chromatin: how enhancer–promoter loops shape daily behavior Weidemann, Benjamin J. Ramsey, Kathryn Moynihan Bass, Joseph Genes Dev Outlook Each spring, we get out of bed 1 h ahead of our biological wake-up time due to the misalignment of internal clocks with the light–dark cycle. Genetic discoveries revealed that clock genes encode transcription factors that are expressed throughout many tissues, yet a gap has remained in understanding the temporal dynamics of transcription. Two groups now apply circular chromosome conformation capture and high-throughput sequencing to dissect how “time of day”-dependent changes in chromatin drive core clock oscillations. A surprise is the finding that disruption of enhancer–promoter contacts within chromatin leads to an advance in the “wake-up” time of mice. Furthermore, the assembly of transcriptionally active domains of chromatin requires the ordered recruitment of core clock transcription factors each day. These studies show that waking up involves highly dynamic changes in the three-dimensional positioning of genes within the cell. Cold Spring Harbor Laboratory Press 2018-03-01 /pmc/articles/PMC5900705/ /pubmed/29593064 http://dx.doi.org/10.1101/gad.314187.118 Text en © 2018 Weidemann et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by/4.0/ This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
spellingShingle Outlook
Weidemann, Benjamin J.
Ramsey, Kathryn Moynihan
Bass, Joseph
A day in the life of chromatin: how enhancer–promoter loops shape daily behavior
title A day in the life of chromatin: how enhancer–promoter loops shape daily behavior
title_full A day in the life of chromatin: how enhancer–promoter loops shape daily behavior
title_fullStr A day in the life of chromatin: how enhancer–promoter loops shape daily behavior
title_full_unstemmed A day in the life of chromatin: how enhancer–promoter loops shape daily behavior
title_short A day in the life of chromatin: how enhancer–promoter loops shape daily behavior
title_sort day in the life of chromatin: how enhancer–promoter loops shape daily behavior
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900705/
https://www.ncbi.nlm.nih.gov/pubmed/29593064
http://dx.doi.org/10.1101/gad.314187.118
work_keys_str_mv AT weidemannbenjaminj adayinthelifeofchromatinhowenhancerpromoterloopsshapedailybehavior
AT ramseykathrynmoynihan adayinthelifeofchromatinhowenhancerpromoterloopsshapedailybehavior
AT bassjoseph adayinthelifeofchromatinhowenhancerpromoterloopsshapedailybehavior
AT weidemannbenjaminj dayinthelifeofchromatinhowenhancerpromoterloopsshapedailybehavior
AT ramseykathrynmoynihan dayinthelifeofchromatinhowenhancerpromoterloopsshapedailybehavior
AT bassjoseph dayinthelifeofchromatinhowenhancerpromoterloopsshapedailybehavior