Cargando…

Structural and functional analysis of the DOT1L–AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis

The mixed-lineage leukemia (MLL)-AF10 fusion oncoprotein recruits DOT1L to the homeobox A (HOXA) gene cluster through its octapeptide motif leucine zipper (OM-LZ), thereby inducing and maintaining the MLL-AF10-associated leukemogenesis. However, the recognition mechanism between DOT1L and MLL-AF10 i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Heng, Zhou, Bo, Qin, Su, Xu, Jing, Harding, Rachel, Tempel, Wolfram, Nayak, Vinod, Li, Yanjun, Loppnau, Peter, Dou, Yali, Min, Jinrong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2018
Materias:	Research Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900708/ https://www.ncbi.nlm.nih.gov/pubmed/29563185 http://dx.doi.org/10.1101/gad.311639.118

Ejemplares similares

Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis
por: Bagislar, Sevgi, et al.
Publicado: (2016)

HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis
por: Takahashi, Satoshi, et al.
Publicado: (2021)

The RNA-binding protein IGF2BP3 is critical for MLL-AF4-mediated leukemogenesis
por: Tran, Tiffany M., et al.
Publicado: (2021)

Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair
por: Castaño, Julio, et al.
Publicado: (2016)

Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis
por: Grigsby, Sierrah M., et al.
Publicado: (2021)

The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations
por: Klein, Brianna J., et al.
Publicado: (2021)

Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1C
por: Zhou, Kuangguo, et al.
Publicado: (2021)

MLL-AF10阳性急性白血病的临床特征及预后分析
Publicado: (2015)

CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis
por: Sarrou, Evgenia, et al.
Publicado: (2020)

circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression
por: Huang, Wei, et al.
Publicado: (2019)

Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus
por: Gyárfás, Tobias, et al.
Publicado: (2016)

Histone H3K36me2-Specific Methyltransferase ASH1L Promotes MLL-AF9-Induced Leukemogenesis
por: Aljazi, Mohammad B., et al.
Publicado: (2021)

Bone marrow mesenchymal stem cells from infants with MLL-AF4(+) acute leukemia harbor and express the MLL-AF4 fusion gene
por: Menendez, Pablo, et al.
Publicado: (2009)

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions
por: Bueno, Clara, et al.
Publicado: (2019)

The mechanism of MYB transcriptional regulation by MLL-AF9 oncoprotein
por: Cao, Lu, et al.
Publicado: (2019)

Molecular studies reveal MLL-MLLT10/AF10 and ARID5B-MLL gene fusions displaced in a case of infantile acute lymphoblastic leukemia with complex karyotype
por: Hiwatari, Mitsuteru, et al.
Publicado: (2017)

Mesures magnetiques des dipoles type 1, 4af, 9af, 10af du booster en regime pulse
por: Chanel, M, et al.
Publicado: (1981)

Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells
por: Liu, Y, et al.
Publicado: (2014)

MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia
por: Prange, K H M, et al.
Publicado: (2017)

AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D(3)
por: Ahmad, Khalil, et al.
Publicado: (2015)

Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL
por: Ahmad, K, et al.
Publicado: (2014)

Human MLL-AF9 Overexpression Induces Aberrant Hematopoietic Expansion in Zebrafish
por: Tan, Jiaqi, et al.
Publicado: (2018)

MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
por: Chen, Xinyue, et al.
Publicado: (2019)

Protocol to establish a stable MLL-AF9_AML mouse model
por: Lu, Jun, et al.
Publicado: (2022)

Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia
por: Tirtakusuma, Ricky, et al.
Publicado: (2022)

Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited
por: Gué, Michaël, et al.
Publicado: (2006)

AFS Monitoring: The CERN AFS Console
por: Wiebalck, Arne
Publicado: (2008)

Zoledronic acid inhibits the growth of leukemic MLL-AF9 transformed hematopoietic cells
por: Chiarella, Emanuela, et al.
Publicado: (2020)

Corrigendum to “Human MLL-AF9 Overexpression Induces Aberrant Hematopoietic Expansion in Zebrafish”
por: Tan, Jiaqi, et al.
Publicado: (2022)

Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis
por: Ballabio, Erica, et al.
Publicado: (2012)

The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis
por: Mahmoudi, Tokameh, et al.
Publicado: (2010)

Mug{AF}amar{AF}at Farn{AF}ats{AF}i == Farnatchi au bal masqué == Farnatchi at the masked ball /
por: Fayard, Roland
Publicado: (1997)

RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes
por: Fleischmann, Katrin K, et al.
Publicado: (2014)

Publisher Correction: MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
por: Chen, Xinyue, et al.
Publicado: (2020)

Isolated meningeal myeloid sarcoma with recurrent MLL-AF6 translocation: a case report
por: Wang, Chunyan, et al.
Publicado: (2023)

Correction: The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis
por: Mahmoudi, Tokameh, et al.
Publicado: (2017)

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia
por: Kerry, Jon, et al.
Publicado: (2017)

PAFc, a Key Player in MLL-rearranged Leukemogenesis
por: Tan, Jiaying, et al.
Publicado: (2010)

Overophedning af partikelaccelerator var frygtet af forskere
Publicado: (2008)

AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation
por: Uğurlu-Çimen, Deniz, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2aa3rrr15u0p7t5qtag1galtv4