Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m(6)A machinery component Wtap/Fl(2)d

N(6)-methyladenosine (m(6)A) is the most abundant mRNA modification in eukaryotes, playing crucial roles in multiple biological processes. m(6)A is catalyzed by the activity of methyltransferase-like 3 (Mettl3), which depends on additional proteins whose precise functions remain poorly understood. H...

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Detalles Bibliográficos
Autores principales: Knuckles, Philip, Lence, Tina, Haussmann, Irmgard U., Jacob, Dominik, Kreim, Nastasja, Carl, Sarah H., Masiello, Irene, Hares, Tina, Villaseñor, Rodrigo, Hess, Daniel, Andrade-Navarro, Miguel A., Biggiogera, Marco, Helm, Mark, Soller, Matthias, Bühler, Marc, Roignant, Jean-Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900714/
https://www.ncbi.nlm.nih.gov/pubmed/29535189
http://dx.doi.org/10.1101/gad.309146.117

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