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Functional connectivity in dementia with Lewy bodies: A within‐ and between‐network analysis
Dementia with Lewy bodies (DLB) is a common form of dementia and is characterized by cognitive fluctuations, visual hallucinations, and Parkinsonism. The phenotypic expression of the disease may, in part, relate to alterations in functional connectivity within and between brain networks. This restin...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900719/ https://www.ncbi.nlm.nih.gov/pubmed/29193464 http://dx.doi.org/10.1002/hbm.23901 |
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author | Schumacher, Julia Peraza, Luis R. Firbank, Michael Thomas, Alan J. Kaiser, Marcus Gallagher, Peter O'Brien, John T. Blamire, Andrew M. Taylor, John‐Paul |
author_facet | Schumacher, Julia Peraza, Luis R. Firbank, Michael Thomas, Alan J. Kaiser, Marcus Gallagher, Peter O'Brien, John T. Blamire, Andrew M. Taylor, John‐Paul |
author_sort | Schumacher, Julia |
collection | PubMed |
description | Dementia with Lewy bodies (DLB) is a common form of dementia and is characterized by cognitive fluctuations, visual hallucinations, and Parkinsonism. The phenotypic expression of the disease may, in part, relate to alterations in functional connectivity within and between brain networks. This resting‐state study sought to clarify this in DLB, how networks differed from Alzheimer's disease (AD), and whether they were related to clinical symptoms in DLB. Resting‐state networks were estimated using independent component analysis. We investigated functional connectivity changes in 31 DLB patients compared to 31 healthy controls and a disease comparator group of 29 AD patients using dual regression and FSLNets. Within‐network connectivity was generally decreased in DLB compared to controls, mainly in motor, temporal, and frontal networks. Between‐network connectivity was mainly intact; only the connection between a frontal and a temporal network showed increased connectivity in DLB. Differences between AD and DLB were subtle and we did not find any significant correlations with the severity of clinical symptoms in DLB. This study emphasizes the importance of reduced connectivity within motor, frontal, and temporal networks in DLB with relative sparing of the default mode network. The lack of significant correlations between connectivity measures and clinical scores indicates that the observed reduced connectivity within these networks might be related to the presence, but not to the severity of motor and cognitive impairment in DLB patients. Furthermore, our results suggest that AD and DLB may show more similarities than differences in patients with mild disease. |
format | Online Article Text |
id | pubmed-5900719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59007192018-05-01 Functional connectivity in dementia with Lewy bodies: A within‐ and between‐network analysis Schumacher, Julia Peraza, Luis R. Firbank, Michael Thomas, Alan J. Kaiser, Marcus Gallagher, Peter O'Brien, John T. Blamire, Andrew M. Taylor, John‐Paul Hum Brain Mapp Research Articles Dementia with Lewy bodies (DLB) is a common form of dementia and is characterized by cognitive fluctuations, visual hallucinations, and Parkinsonism. The phenotypic expression of the disease may, in part, relate to alterations in functional connectivity within and between brain networks. This resting‐state study sought to clarify this in DLB, how networks differed from Alzheimer's disease (AD), and whether they were related to clinical symptoms in DLB. Resting‐state networks were estimated using independent component analysis. We investigated functional connectivity changes in 31 DLB patients compared to 31 healthy controls and a disease comparator group of 29 AD patients using dual regression and FSLNets. Within‐network connectivity was generally decreased in DLB compared to controls, mainly in motor, temporal, and frontal networks. Between‐network connectivity was mainly intact; only the connection between a frontal and a temporal network showed increased connectivity in DLB. Differences between AD and DLB were subtle and we did not find any significant correlations with the severity of clinical symptoms in DLB. This study emphasizes the importance of reduced connectivity within motor, frontal, and temporal networks in DLB with relative sparing of the default mode network. The lack of significant correlations between connectivity measures and clinical scores indicates that the observed reduced connectivity within these networks might be related to the presence, but not to the severity of motor and cognitive impairment in DLB patients. Furthermore, our results suggest that AD and DLB may show more similarities than differences in patients with mild disease. John Wiley and Sons Inc. 2017-11-29 /pmc/articles/PMC5900719/ /pubmed/29193464 http://dx.doi.org/10.1002/hbm.23901 Text en © 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Schumacher, Julia Peraza, Luis R. Firbank, Michael Thomas, Alan J. Kaiser, Marcus Gallagher, Peter O'Brien, John T. Blamire, Andrew M. Taylor, John‐Paul Functional connectivity in dementia with Lewy bodies: A within‐ and between‐network analysis |
title | Functional connectivity in dementia with Lewy bodies: A within‐ and between‐network analysis |
title_full | Functional connectivity in dementia with Lewy bodies: A within‐ and between‐network analysis |
title_fullStr | Functional connectivity in dementia with Lewy bodies: A within‐ and between‐network analysis |
title_full_unstemmed | Functional connectivity in dementia with Lewy bodies: A within‐ and between‐network analysis |
title_short | Functional connectivity in dementia with Lewy bodies: A within‐ and between‐network analysis |
title_sort | functional connectivity in dementia with lewy bodies: a within‐ and between‐network analysis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900719/ https://www.ncbi.nlm.nih.gov/pubmed/29193464 http://dx.doi.org/10.1002/hbm.23901 |
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