Selective C(sp(3))−H Aerobic Oxidation Enabled by Decatungstate Photocatalysis in Flow

A mild and selective C(sp(3))−H aerobic oxidation enabled by decatungstate photocatalysis has been developed. The reaction can be significantly improved in a microflow reactor enabling the safe use of oxygen and enhanced irradiation of the reaction mixture. Our method allows for the oxidation of bot...

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Detalles Bibliográficos
Autores principales: Laudadio, Gabriele, Govaerts, Sebastian, Wang, Ying, Ravelli, Davide, Koolman, Hannes F., Fagnoni, Maurizio, Djuric, Stevan W., Noël, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900731/
https://www.ncbi.nlm.nih.gov/pubmed/29451725
http://dx.doi.org/10.1002/anie.201800818
Descripción
Sumario:A mild and selective C(sp(3))−H aerobic oxidation enabled by decatungstate photocatalysis has been developed. The reaction can be significantly improved in a microflow reactor enabling the safe use of oxygen and enhanced irradiation of the reaction mixture. Our method allows for the oxidation of both activated and unactivated C−H bonds (30 examples). The ability to selectively oxidize natural scaffolds, such as (−)‐ambroxide, pregnenolone acetate, (+)‐sclareolide, and artemisinin, exemplifies the utility of this new method.

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