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An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation

Different immune activation states require distinct metabolic features and activities in immune cells. For instance, inhibition of fatty acid synthase (FASN), which catalyzes the synthesis of long-chain fatty acids, prevents the proinflammatory response in macrophages; however, the precise role of t...

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Detalles Bibliográficos
Autores principales:	Carroll, Richard G., Zasłona, Zbigniew, Galván-Peña, Silvia, Koppe, Emma L., Sévin, Daniel C., Angiari, Stefano, Triantafilou, Martha, Triantafilou, Kathy, Modis, Louise K., O'Neill, Luke A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900750/ https://www.ncbi.nlm.nih.gov/pubmed/29463677 http://dx.doi.org/10.1074/jbc.RA118.001921

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