Cargando…

A Chimeric NaV1.8 Channel Expression System Based on HEK293T Cell Line

Among the nine voltage-gated sodium channel (NaV) subtypes, NaV1.8 is an attractive therapeutic target for pain. The heterologous expression of recombinant NaV1.8 currents is of particular importance for its electrophysiological and pharmacological studies. However, NaV1.8 expresses no or low-level...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Xi, Zhang, Yunxiao, Tang, Dongfang, Liang, Songping, Chen, Ping, Tang, Cheng, Liu, Zhonghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900924/ https://www.ncbi.nlm.nih.gov/pubmed/29686617 http://dx.doi.org/10.3389/fphar.2018.00337

Ejemplares similares

Electrophysiological and Pharmacological Analyses of Na(v)1.9 Voltage-Gated Sodium Channel by Establishing a Heterologous Expression System
por: Zhou, Xi, et al.
Publicado: (2017)

Biophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells
por: Lin, Zhixin, et al.
Publicado: (2016)

ZnO Quantum Dots Induced Oxidative Stress and Apoptosis in HeLa and HEK-293T Cell Lines
por: Yang, Yanjie, et al.
Publicado: (2020)

Supramolecular clustering of the cardiac sodium channel Nav1.5 in HEK293F cells, with and without the auxiliary β3‐subunit
por: Salvage, Samantha C., et al.
Publicado: (2020)

The Natural Flavone Acacetin Blocks Small Conductance Ca(2+)-Activated K(+) Channels Stably Expressed in HEK 293 Cells
por: Chen, Kui-Hao, et al.
Publicado: (2017)

Left-Shifted Nav Channels in Injured Bilayer: Primary Targets for Neuroprotective Nav Antagonists?
por: Morris, Catherine E., et al.
Publicado: (2012)

The opioid tramadol blocks the cardiac sodium channel Na(v)1.5 in HEK293 cells
por: Jia, Lixia, et al.
Publicado: (2023)

HEK293T cell lines defective for O-linked glycosylation
por: Termini, James M., et al.
Publicado: (2017)

Allitridi Inhibits Multiple Cardiac Potassium Channels Expressed in HEK 293 Cells
por: Xu, Xiao-Hui, et al.
Publicado: (2012)

Lack of current observed in HEK293 cells expressing NALCN channels
por: Egan, Jennifer M., et al.
Publicado: (2018)

A Novel Spider Toxin Inhibits Fast Inactivation of the Na(v)1.9 Channel by Binding to Domain III and Domain IV Voltage Sensors
por: Peng, Shuijiao, et al.
Publicado: (2021)

Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line
por: Xiao, Zhihui, et al.
Publicado: (2017)

Cholesterol Down-Regulates BK Channels Stably Expressed in HEK 293 Cells
por: Wu, Wei, et al.
Publicado: (2013)

Effects of equol on multiple K(+) channels stably expressed in HEK 293 cells
por: Deng, Xiu-Ling, et al.
Publicado: (2017)

Data on the construction of a recombinant HEK293 cell line overexpressing hERG potassium channel and examining the presence of hERG mRNA and protein expression
por: Teah, Yi Fan, et al.
Publicado: (2017)

Cloning, Expression and Characterization of Zebra Fish Ferroportin in Hek 293T Cell Line
por: Rafiee, A, et al.
Publicado: (2012)

Inducible HEK293 AAV packaging cell lines expressing Rep proteins
por: Jalšić, Lovro, et al.
Publicado: (2023)

Protective Effects of Smilax glabra Roxb. Against Lead-Induced Renal Oxidative Stress, Inflammation and Apoptosis in Weaning Rats and HEK-293 Cells
por: Shi, Yueyue, et al.
Publicado: (2020)

Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells
por: Yu, Dahai, et al.
Publicado: (2017)

Electrophysiological properties of mouse and epitope-tagged human cardiac sodium channel Na (v)1.5 expressed in HEK293 cells
por: Reinhard, Katja, et al.
Publicado: (2013)

Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 Comparison
por: Loussouarn, Gildas, et al.
Publicado: (2016)

Influence of androgenic blockade with flutamide on pain behaviour and expression of the genes that encode the NaV1.7 and NaV1.8 voltage-dependent sodium channels in a rat model of postoperative pain
por: Barbosa Neto, José Osvaldo, et al.
Publicado: (2019)

Evolution from adherent to suspension: systems biology of HEK293 cell line development
por: Malm, Magdalena, et al.
Publicado: (2020)

Generation and utilization of a HEK-293T murine GM-CSF expressing cell line
por: Robinson, Elektra Kantzari, et al.
Publicado: (2021)

Designing and evaluation of MERS-CoV siRNAs in HEK-293 cell line
por: Sohrab, Sayed Sartaj, et al.
Publicado: (2021)

HEK293 Cell Line as a Platform to Produce Recombinant Proteins and Viral Vectors
por: Tan, Evan, et al.
Publicado: (2021)

Development of HEK-293 Cell Lines Constitutively Expressing Flaviviral Antigens for Use in Diagnostics
por: Powers, Jordan A., et al.
Publicado: (2022)

Engineering of highly potent and selective HNTX-III mutant against hNa(v)1.7 sodium channel for treatment of pain
por: Zhang, Yunxiao, et al.
Publicado: (2021)

Inhibition of the Nav1.7 Channel in the Trigeminal Ganglion Relieves Pulpitis Inflammatory Pain
por: Kwon, Minjee, et al.
Publicado: (2021)

Exposure to 1.8 GHz radiofrequency field modulates ROS in human HEK293 cells as a function of signal amplitude
por: Pooam, Marootpong, et al.
Publicado: (2022)

Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells
por: Chu, Xi, et al.
Publicado: (2015)

Regulation of Kv4.2 A-Type Potassium Channels in HEK-293 Cells by Hypoxia
por: Liu, Yu-Qiang, et al.
Publicado: (2014)

The expression of endogenous voltage‐gated potassium channels in HEK293 cells is affected by culture conditions
por: Ponce, Arturo, et al.
Publicado: (2018)

Animal Toxins Can Alter the Function of Nav1.8 and Nav1.9
por: Gilchrist, John, et al.
Publicado: (2012)

Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas
por: Bird, Emma V, et al.
Publicado: (2013)

The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer
por: Luo, Qianxuan, et al.
Publicado: (2020)

Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines
por: CHEN, XIAO-MENG, et al.
Publicado: (2016)

Scalable Lentiviral Vector Production Using Stable HEK293SF Producer Cell Lines
por: Manceur, Aziza P., et al.
Publicado: (2017)

Effect of ABCB1 genetic polymorphisms on the transport of rivaroxaban in HEK293 recombinant cell lines
por: Sennesael, Anne-Laure, et al.
Publicado: (2018)

Enhancing the Butyrylcholinesterase Activity in HEK-293 Cell Line by Dual-Promoter Vector Decorated on Lipofectamine
por: Mirzaie, Vida, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_nlihnv3dirv1clqt426jp7l1lk