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National audit of perinatal HIV infections in the UK, 2006–2013: what lessons can be learnt?
OBJECTIVES: The aim of the study was to investigate circumstances surrounding perinatal transmissions of HIV (PHIVs) in the UK. METHODS: The National Study of HIV in Pregnancy and Childhood conducts comprehensive surveillance of all pregnancies in women diagnosed with HIV infection and their infants...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901012/ https://www.ncbi.nlm.nih.gov/pubmed/29336508 http://dx.doi.org/10.1111/hiv.12577 |
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author | Peters, H Thorne, C Tookey, PA Byrne, L |
author_facet | Peters, H Thorne, C Tookey, PA Byrne, L |
author_sort | Peters, H |
collection | PubMed |
description | OBJECTIVES: The aim of the study was to investigate circumstances surrounding perinatal transmissions of HIV (PHIVs) in the UK. METHODS: The National Study of HIV in Pregnancy and Childhood conducts comprehensive surveillance of all pregnancies in women diagnosed with HIV infection and their infants in the UK; reports of all HIV‐diagnosed children are also sought, regardless of country of birth. Children with PHIV born in 2006–2013 and reported by 2014 were included in an audit, with additional data collection via telephone interviews with clinicians involved in each case. Contributing factors for each transmission were identified, and cases described according to main likely contributing factor, by maternal diagnosis timing. RESULTS: A total of 108 PHIVs were identified. Of the 41 (38%) infants whose mothers were diagnosed before delivery, it is probable that most were infected in utero, around 20% intrapartum and 20% through breastfeeding. Timing of transmission was unknown for most children of undiagnosed mothers. For infants born to diagnosed women, the most common contributing factors for transmission were difficulties with engagement and/or antiretroviral therapy (ART) adherence in pregnancy (14 of 41) and late antenatal booking (nine of 41); for the 67 children with undiagnosed mothers, these were decline of HIV testing (28 of 67) and seroconversion (23 of 67). Adverse social circumstances around the time of pregnancy were reported for 53% of women, including uncertain immigration status, housing problems and intimate partner violence. Eight children died, all born to undiagnosed mothers. CONCLUSIONS: Priority areas requiring improvement include reducing incident infections, improving ART adherence and facilitating better engagement in care, with attention to addressing the health inequalities and adverse social situations faced by these women. |
format | Online Article Text |
id | pubmed-5901012 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59010122018-04-24 National audit of perinatal HIV infections in the UK, 2006–2013: what lessons can be learnt? Peters, H Thorne, C Tookey, PA Byrne, L HIV Med Original Research OBJECTIVES: The aim of the study was to investigate circumstances surrounding perinatal transmissions of HIV (PHIVs) in the UK. METHODS: The National Study of HIV in Pregnancy and Childhood conducts comprehensive surveillance of all pregnancies in women diagnosed with HIV infection and their infants in the UK; reports of all HIV‐diagnosed children are also sought, regardless of country of birth. Children with PHIV born in 2006–2013 and reported by 2014 were included in an audit, with additional data collection via telephone interviews with clinicians involved in each case. Contributing factors for each transmission were identified, and cases described according to main likely contributing factor, by maternal diagnosis timing. RESULTS: A total of 108 PHIVs were identified. Of the 41 (38%) infants whose mothers were diagnosed before delivery, it is probable that most were infected in utero, around 20% intrapartum and 20% through breastfeeding. Timing of transmission was unknown for most children of undiagnosed mothers. For infants born to diagnosed women, the most common contributing factors for transmission were difficulties with engagement and/or antiretroviral therapy (ART) adherence in pregnancy (14 of 41) and late antenatal booking (nine of 41); for the 67 children with undiagnosed mothers, these were decline of HIV testing (28 of 67) and seroconversion (23 of 67). Adverse social circumstances around the time of pregnancy were reported for 53% of women, including uncertain immigration status, housing problems and intimate partner violence. Eight children died, all born to undiagnosed mothers. CONCLUSIONS: Priority areas requiring improvement include reducing incident infections, improving ART adherence and facilitating better engagement in care, with attention to addressing the health inequalities and adverse social situations faced by these women. John Wiley and Sons Inc. 2018-01-16 2018-04 /pmc/articles/PMC5901012/ /pubmed/29336508 http://dx.doi.org/10.1111/hiv.12577 Text en © 2018 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Peters, H Thorne, C Tookey, PA Byrne, L National audit of perinatal HIV infections in the UK, 2006–2013: what lessons can be learnt? |
title | National audit of perinatal HIV infections in the UK, 2006–2013: what lessons can be learnt? |
title_full | National audit of perinatal HIV infections in the UK, 2006–2013: what lessons can be learnt? |
title_fullStr | National audit of perinatal HIV infections in the UK, 2006–2013: what lessons can be learnt? |
title_full_unstemmed | National audit of perinatal HIV infections in the UK, 2006–2013: what lessons can be learnt? |
title_short | National audit of perinatal HIV infections in the UK, 2006–2013: what lessons can be learnt? |
title_sort | national audit of perinatal hiv infections in the uk, 2006–2013: what lessons can be learnt? |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901012/ https://www.ncbi.nlm.nih.gov/pubmed/29336508 http://dx.doi.org/10.1111/hiv.12577 |
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