Role of microRNA Pathway in Mental Retardation

Deficits in cognitive functions lead to mental retardation (MR). Understanding the genetic basis of inherited MR has provided insights into the pathogenesis of MR. Fragile X syndrome is one of the most common forms of inherited MR, caused by the loss of functional Fragile X Mental Retardation Protei...

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Detalles Bibliográficos
Autores principales: Qurashi, Abrar, Chang, Shuang, Jin, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2007
Materias:
Mini-Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901149/
https://www.ncbi.nlm.nih.gov/pubmed/17982588
http://dx.doi.org/10.1100/tsw.2007.208
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author Qurashi, Abrar
Chang, Shuang
Jin, Peng
author_facet Qurashi, Abrar
Chang, Shuang
Jin, Peng
author_sort Qurashi, Abrar
collection PubMed
description Deficits in cognitive functions lead to mental retardation (MR). Understanding the genetic basis of inherited MR has provided insights into the pathogenesis of MR. Fragile X syndrome is one of the most common forms of inherited MR, caused by the loss of functional Fragile X Mental Retardation Protein (FMRP). MicroRNAs (miRNAs) are endogenous, single-stranded RNAs between 18 and 25 nucleotides in length, which have been implicated in diversified biological pathways. Recent studies have linked the miRNA pathway to fragile X syndrome. Here we review the role of the miRNA pathway in fragile X syndrome and discuss its implication in MR in general.
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spelling pubmed-59011492018-06-03 Role of microRNA Pathway in Mental Retardation Qurashi, Abrar Chang, Shuang Jin, Peng ScientificWorldJournal Mini-Review Article Deficits in cognitive functions lead to mental retardation (MR). Understanding the genetic basis of inherited MR has provided insights into the pathogenesis of MR. Fragile X syndrome is one of the most common forms of inherited MR, caused by the loss of functional Fragile X Mental Retardation Protein (FMRP). MicroRNAs (miRNAs) are endogenous, single-stranded RNAs between 18 and 25 nucleotides in length, which have been implicated in diversified biological pathways. Recent studies have linked the miRNA pathway to fragile X syndrome. Here we review the role of the miRNA pathway in fragile X syndrome and discuss its implication in MR in general. TheScientificWorldJOURNAL 2007-11-02 /pmc/articles/PMC5901149/ /pubmed/17982588 http://dx.doi.org/10.1100/tsw.2007.208 Text en Copyright © 2007 Abrar Qurashi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini-Review Article
Qurashi, Abrar
Chang, Shuang
Jin, Peng
Role of microRNA Pathway in Mental Retardation
title Role of microRNA Pathway in Mental Retardation
title_full Role of microRNA Pathway in Mental Retardation
title_fullStr Role of microRNA Pathway in Mental Retardation
title_full_unstemmed Role of microRNA Pathway in Mental Retardation
title_short Role of microRNA Pathway in Mental Retardation
title_sort role of microrna pathway in mental retardation
topic Mini-Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901149/
https://www.ncbi.nlm.nih.gov/pubmed/17982588
http://dx.doi.org/10.1100/tsw.2007.208
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AT jinpeng roleofmicrornapathwayinmentalretardation

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