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TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models
A considerable body of experimental evidence suggests that tumor necrosis factor (TNF)-α plays a major role in several aspects of inflammation and shock. In particular, it is pivotal in many detrimental effects of acute pancreatitis, and it represents a major determinant of the systemic progression...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
TheScientificWorldJOURNAL
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901214/ https://www.ncbi.nlm.nih.gov/pubmed/17450307 http://dx.doi.org/10.1100/tsw.2007.98 |
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author | Malleo, Giuseppe Mazzon, Emanuela Siriwardena, Ajith K. Cuzzocrea, Salvatore |
author_facet | Malleo, Giuseppe Mazzon, Emanuela Siriwardena, Ajith K. Cuzzocrea, Salvatore |
author_sort | Malleo, Giuseppe |
collection | PubMed |
description | A considerable body of experimental evidence suggests that tumor necrosis factor (TNF)-α plays a major role in several aspects of inflammation and shock. In particular, it is pivotal in many detrimental effects of acute pancreatitis, and it represents a major determinant of the systemic progression and end-organ damage (such as acute lung injury and liver failure) of this pathologic condition. Given the importance of TNF-α in the pathogenesis of acute pancreatitis, investigators have regarded blocking the action of this mediator as an attractive treatment option. Different specific and nonspecific inhibitors have been developed with promising results in animal models, but, on the other hand, no clinical trials have been designed so far. Difficulties in clinical applications may be multifactorial; experimental models are not fully reliable and reproduce at least some aspects of human disease, timing of intervention should be related to changes in TNF-α serum levels, and inclusion criteria should be accurately selected to better define the population most likely to benefit. |
format | Online Article Text |
id | pubmed-5901214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | TheScientificWorldJOURNAL |
record_format | MEDLINE/PubMed |
spelling | pubmed-59012142018-06-03 TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models Malleo, Giuseppe Mazzon, Emanuela Siriwardena, Ajith K. Cuzzocrea, Salvatore ScientificWorldJournal Review Article A considerable body of experimental evidence suggests that tumor necrosis factor (TNF)-α plays a major role in several aspects of inflammation and shock. In particular, it is pivotal in many detrimental effects of acute pancreatitis, and it represents a major determinant of the systemic progression and end-organ damage (such as acute lung injury and liver failure) of this pathologic condition. Given the importance of TNF-α in the pathogenesis of acute pancreatitis, investigators have regarded blocking the action of this mediator as an attractive treatment option. Different specific and nonspecific inhibitors have been developed with promising results in animal models, but, on the other hand, no clinical trials have been designed so far. Difficulties in clinical applications may be multifactorial; experimental models are not fully reliable and reproduce at least some aspects of human disease, timing of intervention should be related to changes in TNF-α serum levels, and inclusion criteria should be accurately selected to better define the population most likely to benefit. TheScientificWorldJOURNAL 2007-03-30 /pmc/articles/PMC5901214/ /pubmed/17450307 http://dx.doi.org/10.1100/tsw.2007.98 Text en Copyright © 2007 Giuseppe Malleo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Malleo, Giuseppe Mazzon, Emanuela Siriwardena, Ajith K. Cuzzocrea, Salvatore TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models |
title | TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models |
title_full | TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models |
title_fullStr | TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models |
title_full_unstemmed | TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models |
title_short | TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models |
title_sort | tnf-α as a therapeutic target in acute pancreatitis — lessons from experimental models |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901214/ https://www.ncbi.nlm.nih.gov/pubmed/17450307 http://dx.doi.org/10.1100/tsw.2007.98 |
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