Cargando…

TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models

A considerable body of experimental evidence suggests that tumor necrosis factor (TNF)-α plays a major role in several aspects of inflammation and shock. In particular, it is pivotal in many detrimental effects of acute pancreatitis, and it represents a major determinant of the systemic progression...

Descripción completa

Detalles Bibliográficos
Autores principales: Malleo, Giuseppe, Mazzon, Emanuela, Siriwardena, Ajith K., Cuzzocrea, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901214/
https://www.ncbi.nlm.nih.gov/pubmed/17450307
http://dx.doi.org/10.1100/tsw.2007.98
_version_ 1783314566639255552
author Malleo, Giuseppe
Mazzon, Emanuela
Siriwardena, Ajith K.
Cuzzocrea, Salvatore
author_facet Malleo, Giuseppe
Mazzon, Emanuela
Siriwardena, Ajith K.
Cuzzocrea, Salvatore
author_sort Malleo, Giuseppe
collection PubMed
description A considerable body of experimental evidence suggests that tumor necrosis factor (TNF)-α plays a major role in several aspects of inflammation and shock. In particular, it is pivotal in many detrimental effects of acute pancreatitis, and it represents a major determinant of the systemic progression and end-organ damage (such as acute lung injury and liver failure) of this pathologic condition. Given the importance of TNF-α in the pathogenesis of acute pancreatitis, investigators have regarded blocking the action of this mediator as an attractive treatment option. Different specific and nonspecific inhibitors have been developed with promising results in animal models, but, on the other hand, no clinical trials have been designed so far. Difficulties in clinical applications may be multifactorial; experimental models are not fully reliable and reproduce at least some aspects of human disease, timing of intervention should be related to changes in TNF-α serum levels, and inclusion criteria should be accurately selected to better define the population most likely to benefit.
format Online
Article
Text
id pubmed-5901214
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher TheScientificWorldJOURNAL
record_format MEDLINE/PubMed
spelling pubmed-59012142018-06-03 TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models Malleo, Giuseppe Mazzon, Emanuela Siriwardena, Ajith K. Cuzzocrea, Salvatore ScientificWorldJournal Review Article A considerable body of experimental evidence suggests that tumor necrosis factor (TNF)-α plays a major role in several aspects of inflammation and shock. In particular, it is pivotal in many detrimental effects of acute pancreatitis, and it represents a major determinant of the systemic progression and end-organ damage (such as acute lung injury and liver failure) of this pathologic condition. Given the importance of TNF-α in the pathogenesis of acute pancreatitis, investigators have regarded blocking the action of this mediator as an attractive treatment option. Different specific and nonspecific inhibitors have been developed with promising results in animal models, but, on the other hand, no clinical trials have been designed so far. Difficulties in clinical applications may be multifactorial; experimental models are not fully reliable and reproduce at least some aspects of human disease, timing of intervention should be related to changes in TNF-α serum levels, and inclusion criteria should be accurately selected to better define the population most likely to benefit. TheScientificWorldJOURNAL 2007-03-30 /pmc/articles/PMC5901214/ /pubmed/17450307 http://dx.doi.org/10.1100/tsw.2007.98 Text en Copyright © 2007 Giuseppe Malleo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Malleo, Giuseppe
Mazzon, Emanuela
Siriwardena, Ajith K.
Cuzzocrea, Salvatore
TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models
title TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models
title_full TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models
title_fullStr TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models
title_full_unstemmed TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models
title_short TNF-α as a Therapeutic Target in Acute Pancreatitis — Lessons from Experimental Models
title_sort tnf-α as a therapeutic target in acute pancreatitis — lessons from experimental models
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901214/
https://www.ncbi.nlm.nih.gov/pubmed/17450307
http://dx.doi.org/10.1100/tsw.2007.98
work_keys_str_mv AT malleogiuseppe tnfaasatherapeutictargetinacutepancreatitislessonsfromexperimentalmodels
AT mazzonemanuela tnfaasatherapeutictargetinacutepancreatitislessonsfromexperimentalmodels
AT siriwardenaajithk tnfaasatherapeutictargetinacutepancreatitislessonsfromexperimentalmodels
AT cuzzocreasalvatore tnfaasatherapeutictargetinacutepancreatitislessonsfromexperimentalmodels