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Circadian Rhythms, the Mesolimbic Dopaminergic Circuit, and Drug Addiction

Drug addiction is a devastating disease that affects millions of individuals worldwide. Through better understanding of the genetic variations that create a vulnerability for addiction and the molecular mechanisms that underlie the progression of addiction, better treatment options can be created fo...

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Autor principal: McClung, Colleen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901358/
https://www.ncbi.nlm.nih.gov/pubmed/17982593
http://dx.doi.org/10.1100/tsw.2007.213
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author McClung, Colleen A.
author_facet McClung, Colleen A.
author_sort McClung, Colleen A.
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description Drug addiction is a devastating disease that affects millions of individuals worldwide. Through better understanding of the genetic variations that create a vulnerability for addiction and the molecular mechanisms that underlie the progression of addiction, better treatment options can be created for those that suffer from this condition. Recent studies point to a link between abnormal or disrupted circadian rhythms and the development of addiction. In addition, studies suggest a role for specific genes that make up the molecular clock in the regulation of drug sensitivity, sensitization, and reward. The influence of circadian genes and rhythms on drug-induced behaviors may be mediated through the mesolimbic dopaminergic system. This system has long been implicated in the development of addiction, and recent evidence supports a regulatory role for the brain's central pacemaker and circadian gene expression in the regulation of dopaminergic transmission. This review highlights the association between circadian genes and drug addiction, and the possible role of the mesolimbic dopaminergic system in this association.
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spelling pubmed-59013582018-06-03 Circadian Rhythms, the Mesolimbic Dopaminergic Circuit, and Drug Addiction McClung, Colleen A. ScientificWorldJournal Mini-Review Article Drug addiction is a devastating disease that affects millions of individuals worldwide. Through better understanding of the genetic variations that create a vulnerability for addiction and the molecular mechanisms that underlie the progression of addiction, better treatment options can be created for those that suffer from this condition. Recent studies point to a link between abnormal or disrupted circadian rhythms and the development of addiction. In addition, studies suggest a role for specific genes that make up the molecular clock in the regulation of drug sensitivity, sensitization, and reward. The influence of circadian genes and rhythms on drug-induced behaviors may be mediated through the mesolimbic dopaminergic system. This system has long been implicated in the development of addiction, and recent evidence supports a regulatory role for the brain's central pacemaker and circadian gene expression in the regulation of dopaminergic transmission. This review highlights the association between circadian genes and drug addiction, and the possible role of the mesolimbic dopaminergic system in this association. TheScientificWorldJOURNAL 2007-11-02 /pmc/articles/PMC5901358/ /pubmed/17982593 http://dx.doi.org/10.1100/tsw.2007.213 Text en Copyright © 2007 Colleen A. McClung. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini-Review Article
McClung, Colleen A.
Circadian Rhythms, the Mesolimbic Dopaminergic Circuit, and Drug Addiction
title Circadian Rhythms, the Mesolimbic Dopaminergic Circuit, and Drug Addiction
title_full Circadian Rhythms, the Mesolimbic Dopaminergic Circuit, and Drug Addiction
title_fullStr Circadian Rhythms, the Mesolimbic Dopaminergic Circuit, and Drug Addiction
title_full_unstemmed Circadian Rhythms, the Mesolimbic Dopaminergic Circuit, and Drug Addiction
title_short Circadian Rhythms, the Mesolimbic Dopaminergic Circuit, and Drug Addiction
title_sort circadian rhythms, the mesolimbic dopaminergic circuit, and drug addiction
topic Mini-Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901358/
https://www.ncbi.nlm.nih.gov/pubmed/17982593
http://dx.doi.org/10.1100/tsw.2007.213
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