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Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review
IgG4-related disease (IgG4-RD) is a rare fibroinflammatory condition that can affect almost any organ, characterized by swollen lesions and often by eosinophilia and elevated serum IgG4 concentrations. The diagnosis of IgG4-RD is a challenging task: in fact, single or multiple organs can be affected...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901485/ https://www.ncbi.nlm.nih.gov/pubmed/29805984 http://dx.doi.org/10.1155/2018/6936727 |
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author | Puxeddu, Ilaria Capecchi, Riccardo Carta, Filippo Tavoni, Antonio Gaetano Migliorini, Paola Puxeddu, Roberto |
author_facet | Puxeddu, Ilaria Capecchi, Riccardo Carta, Filippo Tavoni, Antonio Gaetano Migliorini, Paola Puxeddu, Roberto |
author_sort | Puxeddu, Ilaria |
collection | PubMed |
description | IgG4-related disease (IgG4-RD) is a rare fibroinflammatory condition that can affect almost any organ, characterized by swollen lesions and often by eosinophilia and elevated serum IgG4 concentrations. The diagnosis of IgG4-RD is a challenging task: in fact, single or multiple organs can be affected and clinical, serological, and histological findings can be heterogeneous. In IgG4-RD, the involvement of salivary glands is observed in 27% to 53% of patients. Several organ-specific conditions, now recognized as different manifestations of IgG4-related sialadenitis (IgG4-RS), were viewed in the past as individual disease entities. The study of salivary glands may sometimes be complex, because of the number of pathological conditions that may affect them, often with overlapping clinical pictures. Integration of different imaging techniques is often required in the case of swelling of salivary glands, even though biopsy remains the gold standard for a definite diagnosis of IgG4-RS. Thus, in this review, we discuss new insights in the pathogenesis of IgG4-RD, focusing on its clinical aspects and the tools that are currently available for a correct differential diagnosis when the salivary glands are involved. |
format | Online Article Text |
id | pubmed-5901485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-59014852018-05-27 Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review Puxeddu, Ilaria Capecchi, Riccardo Carta, Filippo Tavoni, Antonio Gaetano Migliorini, Paola Puxeddu, Roberto J Immunol Res Review Article IgG4-related disease (IgG4-RD) is a rare fibroinflammatory condition that can affect almost any organ, characterized by swollen lesions and often by eosinophilia and elevated serum IgG4 concentrations. The diagnosis of IgG4-RD is a challenging task: in fact, single or multiple organs can be affected and clinical, serological, and histological findings can be heterogeneous. In IgG4-RD, the involvement of salivary glands is observed in 27% to 53% of patients. Several organ-specific conditions, now recognized as different manifestations of IgG4-related sialadenitis (IgG4-RS), were viewed in the past as individual disease entities. The study of salivary glands may sometimes be complex, because of the number of pathological conditions that may affect them, often with overlapping clinical pictures. Integration of different imaging techniques is often required in the case of swelling of salivary glands, even though biopsy remains the gold standard for a definite diagnosis of IgG4-RS. Thus, in this review, we discuss new insights in the pathogenesis of IgG4-RD, focusing on its clinical aspects and the tools that are currently available for a correct differential diagnosis when the salivary glands are involved. Hindawi 2018-04-01 /pmc/articles/PMC5901485/ /pubmed/29805984 http://dx.doi.org/10.1155/2018/6936727 Text en Copyright © 2018 Ilaria Puxeddu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Puxeddu, Ilaria Capecchi, Riccardo Carta, Filippo Tavoni, Antonio Gaetano Migliorini, Paola Puxeddu, Roberto Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review |
title | Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review |
title_full | Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review |
title_fullStr | Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review |
title_full_unstemmed | Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review |
title_short | Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review |
title_sort | salivary gland pathology in igg4-related disease: a comprehensive review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901485/ https://www.ncbi.nlm.nih.gov/pubmed/29805984 http://dx.doi.org/10.1155/2018/6936727 |
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