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Spatiotemporal expression of MYD88 gene in pigs from birth to adulthood

MYD88 plays an important role in the immune response against infections. To analyze MYD88 gene expression during different stages of pig development, we used real-time PCR. MYD88 was seen expressed in all tissues examined. MYD88 expression in spleen, lungs, and thymus reached its highest value from...

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Autores principales: Gan, LiNa, Qin, WeiYun, Wu, Sen, Wu, ShengLong, Bao, WenBin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901504/
https://www.ncbi.nlm.nih.gov/pubmed/29384556
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0014
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author Gan, LiNa
Qin, WeiYun
Wu, Sen
Wu, ShengLong
Bao, WenBin
author_facet Gan, LiNa
Qin, WeiYun
Wu, Sen
Wu, ShengLong
Bao, WenBin
author_sort Gan, LiNa
collection PubMed
description MYD88 plays an important role in the immune response against infections. To analyze MYD88 gene expression during different stages of pig development, we used real-time PCR. MYD88 was seen expressed in all tissues examined. MYD88 expression in spleen, lungs, and thymus reached its highest value from 7 to 14 days of age and decreased thereafter. Expression in lymph nodes was high until 28 days of age and then it declined after weaning, with stable low levels in adult pigs. MYD88 expression was high before 35 days of age in the small intestine (duodenum, jejunum, and ileum), where it reached its highest value from 7 to 14 days of age. MYD88 expression in the small intestine declined post-weaning and remained relatively low during adulthood. The results of this study suggest that weaning stress and development of the immune system might be positively correlated with MYD88 expression regulation. Moreover, this study provided evidence that the high expression of MYD88 may diminish weaning stress and increase disease resistance in Meishan pigs.
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spelling pubmed-59015042018-04-23 Spatiotemporal expression of MYD88 gene in pigs from birth to adulthood Gan, LiNa Qin, WeiYun Wu, Sen Wu, ShengLong Bao, WenBin Genet Mol Biol Animal Genetics MYD88 plays an important role in the immune response against infections. To analyze MYD88 gene expression during different stages of pig development, we used real-time PCR. MYD88 was seen expressed in all tissues examined. MYD88 expression in spleen, lungs, and thymus reached its highest value from 7 to 14 days of age and decreased thereafter. Expression in lymph nodes was high until 28 days of age and then it declined after weaning, with stable low levels in adult pigs. MYD88 expression was high before 35 days of age in the small intestine (duodenum, jejunum, and ileum), where it reached its highest value from 7 to 14 days of age. MYD88 expression in the small intestine declined post-weaning and remained relatively low during adulthood. The results of this study suggest that weaning stress and development of the immune system might be positively correlated with MYD88 expression regulation. Moreover, this study provided evidence that the high expression of MYD88 may diminish weaning stress and increase disease resistance in Meishan pigs. Sociedade Brasileira de Genética 2018-01-22 2018 /pmc/articles/PMC5901504/ /pubmed/29384556 http://dx.doi.org/10.1590/1678-4685-GMB-2017-0014 Text en Copyright © 2018, Sociedade Brasileira de Genética. https://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Animal Genetics
Gan, LiNa
Qin, WeiYun
Wu, Sen
Wu, ShengLong
Bao, WenBin
Spatiotemporal expression of MYD88 gene in pigs from birth to adulthood
title Spatiotemporal expression of MYD88 gene in pigs from birth to adulthood
title_full Spatiotemporal expression of MYD88 gene in pigs from birth to adulthood
title_fullStr Spatiotemporal expression of MYD88 gene in pigs from birth to adulthood
title_full_unstemmed Spatiotemporal expression of MYD88 gene in pigs from birth to adulthood
title_short Spatiotemporal expression of MYD88 gene in pigs from birth to adulthood
title_sort spatiotemporal expression of myd88 gene in pigs from birth to adulthood
topic Animal Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901504/
https://www.ncbi.nlm.nih.gov/pubmed/29384556
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0014
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