Development and Validation of an LC-MS/MS Method and Comparison with a GC-MS Method to Measure Phenytoin in Human Brain Dialysate, Blood, and Saliva

Phenytoin (PHT) is one of the most often used critical dose drugs, where insufficient or excessive dosing can have severe consequences such as seizures or toxicity. Thus, the monitoring and precise measuring of PHT concentrations in patients is crucial. This study develops and validates an LC-MS/MS...

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Detalles Bibliográficos
Autores principales: Hösli, Raphael, König, Stefan, Mühlebach, Stefan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901821/
https://www.ncbi.nlm.nih.gov/pubmed/29805839
http://dx.doi.org/10.1155/2018/8274131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901821/
https://www.ncbi.nlm.nih.gov/pubmed/29805839
http://dx.doi.org/10.1155/2018/8274131

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