Can chimerism explain breast/ovarian cancers in BRCA non-carriers from BRCA-positive families?

Hereditary breast and ovarian cancer syndrome (HBOC) is most frequently caused by mutations in BRCA1 or BRCA2 (in short, BRCA) genes. The incidence of hereditary breast and ovarian cancer in relatives of BRCA mutation carriers who test negative for the familial mutation (non-carriers) may be increas...

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Detalles Bibliográficos
Autores principales: Mitchell, Rachel, Buckingham, Lela, Cobleigh, Melody, Rotmensch, Jacob, Burgess, Kelly, Usha, Lydia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901986/
https://www.ncbi.nlm.nih.gov/pubmed/29659587
http://dx.doi.org/10.1371/journal.pone.0195497

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