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Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives

The gut environment and gut microbiome dysbiosis have been demonstrated to significantly influence a range of disorders in humans, including obesity, diabetes, rheumatoid arthritis, and multiple sclerosis (MS). MS is an autoimmune disease affecting the central nervous system (CNS). The etiology of M...

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Detalles Bibliográficos
Autores principales: Chu, Fengna, Shi, Mingchao, Lang, Yue, Shen, Donghui, Jin, Tao, Zhu, Jie, Cui, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902007/
https://www.ncbi.nlm.nih.gov/pubmed/29805314
http://dx.doi.org/10.1155/2018/8168717
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author Chu, Fengna
Shi, Mingchao
Lang, Yue
Shen, Donghui
Jin, Tao
Zhu, Jie
Cui, Li
author_facet Chu, Fengna
Shi, Mingchao
Lang, Yue
Shen, Donghui
Jin, Tao
Zhu, Jie
Cui, Li
author_sort Chu, Fengna
collection PubMed
description The gut environment and gut microbiome dysbiosis have been demonstrated to significantly influence a range of disorders in humans, including obesity, diabetes, rheumatoid arthritis, and multiple sclerosis (MS). MS is an autoimmune disease affecting the central nervous system (CNS). The etiology of MS is not clear, and it should involve both genetic and extrinsic factors. The extrinsic factors responsible for predisposition to MS remain elusive. Recent studies on MS and its animal model, experimental autoimmune encephalomyelitis (EAE), have found that gastrointestinal microbiota may play an important role in the pathogenesis of MS/EAE. Thus, gut microbiome adjustment may be a future direction of treatment in MS. In this review, we discuss the characteristics of the gut microbiota, the connection between the brain and the gut, and the changes in gut microbiota in MS/EAE, and we explore the possibility of applying microbiota therapies in patients with MS.
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spelling pubmed-59020072018-05-27 Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives Chu, Fengna Shi, Mingchao Lang, Yue Shen, Donghui Jin, Tao Zhu, Jie Cui, Li Mediators Inflamm Review Article The gut environment and gut microbiome dysbiosis have been demonstrated to significantly influence a range of disorders in humans, including obesity, diabetes, rheumatoid arthritis, and multiple sclerosis (MS). MS is an autoimmune disease affecting the central nervous system (CNS). The etiology of MS is not clear, and it should involve both genetic and extrinsic factors. The extrinsic factors responsible for predisposition to MS remain elusive. Recent studies on MS and its animal model, experimental autoimmune encephalomyelitis (EAE), have found that gastrointestinal microbiota may play an important role in the pathogenesis of MS/EAE. Thus, gut microbiome adjustment may be a future direction of treatment in MS. In this review, we discuss the characteristics of the gut microbiota, the connection between the brain and the gut, and the changes in gut microbiota in MS/EAE, and we explore the possibility of applying microbiota therapies in patients with MS. Hindawi 2018-04-02 /pmc/articles/PMC5902007/ /pubmed/29805314 http://dx.doi.org/10.1155/2018/8168717 Text en Copyright © 2018 Fengna Chu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chu, Fengna
Shi, Mingchao
Lang, Yue
Shen, Donghui
Jin, Tao
Zhu, Jie
Cui, Li
Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives
title Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives
title_full Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives
title_fullStr Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives
title_full_unstemmed Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives
title_short Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives
title_sort gut microbiota in multiple sclerosis and experimental autoimmune encephalomyelitis: current applications and future perspectives
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902007/
https://www.ncbi.nlm.nih.gov/pubmed/29805314
http://dx.doi.org/10.1155/2018/8168717
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