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Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors

The enzyme geranylgeranyl diphosphate synthase (GGDPS) catalyzes the synthesis of the 20-carbon isoprenoid geranylgeranyl diphosphate (GGPP). GGPP is the isoprenoid donor for protein geranylgeranylation reactions catalyzed by the enzymes geranylgeranyl transferase (GGTase) I and II. Inhibitors of GG...

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Detalles Bibliográficos
Autores principales:	Haney, Staci L., Wills, Veronica S., Wiemer, David F., Holstein, Sarah A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902023/ https://www.ncbi.nlm.nih.gov/pubmed/28555000 http://dx.doi.org/10.3390/molecules22060886

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