Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3

Sirtuin 3 (SIRT3) is a NAD(+)-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration and in high-fat diet (HFD)-induced metabolic disorders. Here, we performed a small-molecule screen and identified an unexpected metabolic vulnerability associat...

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Detalles Bibliográficos
Autores principales: Gonzalez Herrera, Karina N., Zaganjor, Elma, Ishikawa, Yoshinori, Spinelli, Jessica B., Yoon, Haejin, Lin, Jia-Ren, Satterstrom, F. Kyle, Ringel, Alison, Mulei, Stacy, Souza, Amanda, Gorham, Joshua M., Benson, Craig C., Seidman, Jonathan G., Sorger, Peter K., Clish, Clary B., Haigis, Marcia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902027/
https://www.ncbi.nlm.nih.gov/pubmed/29466723
http://dx.doi.org/10.1016/j.celrep.2018.01.076

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