Cargando…

Uncommon Infections in Children Suggest Underlying Immunodeficiency: A Case of Infective Endocarditis in a 3-Year-Old Male

Infective endocarditis (IE) results from bacterial or fungal infection and is associated with significant morbidity and mortality. Several known risk factors exist for endocarditis, and 90% of pediatric cases have an underlying structural or congenital heart disease or prosthetic heart valve. Litera...

Descripción completa

Detalles Bibliográficos
Autores principales: Shakoor, Aisha, El-Isa, Ahmed, Kinsella, Elizabeth, Halas, Ryan, Leonov, Andrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902077/
https://www.ncbi.nlm.nih.gov/pubmed/29808135
http://dx.doi.org/10.1155/2018/9380763
_version_ 1783314703337914368
author Shakoor, Aisha
El-Isa, Ahmed
Kinsella, Elizabeth
Halas, Ryan
Leonov, Andrey
author_facet Shakoor, Aisha
El-Isa, Ahmed
Kinsella, Elizabeth
Halas, Ryan
Leonov, Andrey
author_sort Shakoor, Aisha
collection PubMed
description Infective endocarditis (IE) results from bacterial or fungal infection and is associated with significant morbidity and mortality. Several known risk factors exist for endocarditis, and 90% of pediatric cases have an underlying structural or congenital heart disease or prosthetic heart valve. Literature on IE in previously healthy children is relatively sparse, and the pathogenesis and underlying risk factors remain mostly unknown. Our patient was a 3-year-old male with a unique presentation of IE. His lack of structural and congenital risk factors for endocarditis prompted further workup, and labs were consistent with insufficient immunoglobulin, suggesting a primary immunodeficiency (PAD). PAD presents as heightened susceptibility to infections, commonly seen as recurrent pneumonia, meningitis, septic arthritis, and otitis media. Pediatric patients commonly have infections, yet as many as in 1 in 2000 patients have PAD. Our case emphasizes the potential need for further investigation into PAD in a young patient with no known risk factors who develops an uncommon infection such as IE.
format Online
Article
Text
id pubmed-5902077
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-59020772018-05-28 Uncommon Infections in Children Suggest Underlying Immunodeficiency: A Case of Infective Endocarditis in a 3-Year-Old Male Shakoor, Aisha El-Isa, Ahmed Kinsella, Elizabeth Halas, Ryan Leonov, Andrey Case Rep Infect Dis Case Report Infective endocarditis (IE) results from bacterial or fungal infection and is associated with significant morbidity and mortality. Several known risk factors exist for endocarditis, and 90% of pediatric cases have an underlying structural or congenital heart disease or prosthetic heart valve. Literature on IE in previously healthy children is relatively sparse, and the pathogenesis and underlying risk factors remain mostly unknown. Our patient was a 3-year-old male with a unique presentation of IE. His lack of structural and congenital risk factors for endocarditis prompted further workup, and labs were consistent with insufficient immunoglobulin, suggesting a primary immunodeficiency (PAD). PAD presents as heightened susceptibility to infections, commonly seen as recurrent pneumonia, meningitis, septic arthritis, and otitis media. Pediatric patients commonly have infections, yet as many as in 1 in 2000 patients have PAD. Our case emphasizes the potential need for further investigation into PAD in a young patient with no known risk factors who develops an uncommon infection such as IE. Hindawi 2018-04-01 /pmc/articles/PMC5902077/ /pubmed/29808135 http://dx.doi.org/10.1155/2018/9380763 Text en Copyright © 2018 Aisha Shakoor et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Shakoor, Aisha
El-Isa, Ahmed
Kinsella, Elizabeth
Halas, Ryan
Leonov, Andrey
Uncommon Infections in Children Suggest Underlying Immunodeficiency: A Case of Infective Endocarditis in a 3-Year-Old Male
title Uncommon Infections in Children Suggest Underlying Immunodeficiency: A Case of Infective Endocarditis in a 3-Year-Old Male
title_full Uncommon Infections in Children Suggest Underlying Immunodeficiency: A Case of Infective Endocarditis in a 3-Year-Old Male
title_fullStr Uncommon Infections in Children Suggest Underlying Immunodeficiency: A Case of Infective Endocarditis in a 3-Year-Old Male
title_full_unstemmed Uncommon Infections in Children Suggest Underlying Immunodeficiency: A Case of Infective Endocarditis in a 3-Year-Old Male
title_short Uncommon Infections in Children Suggest Underlying Immunodeficiency: A Case of Infective Endocarditis in a 3-Year-Old Male
title_sort uncommon infections in children suggest underlying immunodeficiency: a case of infective endocarditis in a 3-year-old male
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902077/
https://www.ncbi.nlm.nih.gov/pubmed/29808135
http://dx.doi.org/10.1155/2018/9380763
work_keys_str_mv AT shakooraisha uncommoninfectionsinchildrensuggestunderlyingimmunodeficiencyacaseofinfectiveendocarditisina3yearoldmale
AT elisaahmed uncommoninfectionsinchildrensuggestunderlyingimmunodeficiencyacaseofinfectiveendocarditisina3yearoldmale
AT kinsellaelizabeth uncommoninfectionsinchildrensuggestunderlyingimmunodeficiencyacaseofinfectiveendocarditisina3yearoldmale
AT halasryan uncommoninfectionsinchildrensuggestunderlyingimmunodeficiencyacaseofinfectiveendocarditisina3yearoldmale
AT leonovandrey uncommoninfectionsinchildrensuggestunderlyingimmunodeficiencyacaseofinfectiveendocarditisina3yearoldmale