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Capsaicin 8% patch reversibly reduces A-delta fiber evoked potential amplitudes

INTRODUCTION: The capsaicin 8% patch is a treatment option in patients with localized peripheral neuropathic pain. Better understanding of its mechanisms of action and knowledge on predictive biomarkers for a treatment response is warranted. OBJECTIVES: To use electrically evoked pain-related potent...

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Autores principales: Papagianni, Aikaterini, Siedler, Gabriela, Sommer, Claudia, Üçeyler, Nurcan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902250/
https://www.ncbi.nlm.nih.gov/pubmed/29756090
http://dx.doi.org/10.1097/PR9.0000000000000644
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author Papagianni, Aikaterini
Siedler, Gabriela
Sommer, Claudia
Üçeyler, Nurcan
author_facet Papagianni, Aikaterini
Siedler, Gabriela
Sommer, Claudia
Üçeyler, Nurcan
author_sort Papagianni, Aikaterini
collection PubMed
description INTRODUCTION: The capsaicin 8% patch is a treatment option in patients with localized peripheral neuropathic pain. Better understanding of its mechanisms of action and knowledge on predictive biomarkers for a treatment response is warranted. OBJECTIVES: To use electrically evoked pain-related potentials for investigation of A-delta fiber conduction after capsaicin 8% patch treatment. METHODS: We studied 11 healthy controls at the dorsal hand and the foot and 12 patients with neuropathic pain at the area affected by neuropathic pain before and 2 hours after application of a capsaicin 8% patch (Qutenza). Patients were additionally phenotyped using quantitative sensory testing and skin biopsy. RESULTS: Peak-to-peak N1-P1 amplitudes (PPA) were reduced after Qutenza application by a median of 60% in 6/11 controls and by 33% in patients with neuropathic pain compared with baseline; they were increased in 3 controls that did not develop capsaicin-induced pain. Patients with elevated cold detection thresholds more often had reduced PPA after Qutenza than those with normal cold detection threshold. Patients with reduced PPA after capsaicin application and with capsaicin-induced pain were more likely to achieve pain reduction on Qutenza. CONCLUSION: The capsaicin 8% patch induces a reduction in A-delta PPA in healthy persons and in patients with neuropathic pain adding to the mechanistic understanding of its effect.
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spelling pubmed-59022502018-05-11 Capsaicin 8% patch reversibly reduces A-delta fiber evoked potential amplitudes Papagianni, Aikaterini Siedler, Gabriela Sommer, Claudia Üçeyler, Nurcan Pain Rep Neuropathic INTRODUCTION: The capsaicin 8% patch is a treatment option in patients with localized peripheral neuropathic pain. Better understanding of its mechanisms of action and knowledge on predictive biomarkers for a treatment response is warranted. OBJECTIVES: To use electrically evoked pain-related potentials for investigation of A-delta fiber conduction after capsaicin 8% patch treatment. METHODS: We studied 11 healthy controls at the dorsal hand and the foot and 12 patients with neuropathic pain at the area affected by neuropathic pain before and 2 hours after application of a capsaicin 8% patch (Qutenza). Patients were additionally phenotyped using quantitative sensory testing and skin biopsy. RESULTS: Peak-to-peak N1-P1 amplitudes (PPA) were reduced after Qutenza application by a median of 60% in 6/11 controls and by 33% in patients with neuropathic pain compared with baseline; they were increased in 3 controls that did not develop capsaicin-induced pain. Patients with elevated cold detection thresholds more often had reduced PPA after Qutenza than those with normal cold detection threshold. Patients with reduced PPA after capsaicin application and with capsaicin-induced pain were more likely to achieve pain reduction on Qutenza. CONCLUSION: The capsaicin 8% patch induces a reduction in A-delta PPA in healthy persons and in patients with neuropathic pain adding to the mechanistic understanding of its effect. Wolters Kluwer 2018-03-02 /pmc/articles/PMC5902250/ /pubmed/29756090 http://dx.doi.org/10.1097/PR9.0000000000000644 Text en Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike License 4.0 (CC BY-NC-SA) (http://creativecommons.org/licenses/by-nc-sa/4.0/) which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Neuropathic
Papagianni, Aikaterini
Siedler, Gabriela
Sommer, Claudia
Üçeyler, Nurcan
Capsaicin 8% patch reversibly reduces A-delta fiber evoked potential amplitudes
title Capsaicin 8% patch reversibly reduces A-delta fiber evoked potential amplitudes
title_full Capsaicin 8% patch reversibly reduces A-delta fiber evoked potential amplitudes
title_fullStr Capsaicin 8% patch reversibly reduces A-delta fiber evoked potential amplitudes
title_full_unstemmed Capsaicin 8% patch reversibly reduces A-delta fiber evoked potential amplitudes
title_short Capsaicin 8% patch reversibly reduces A-delta fiber evoked potential amplitudes
title_sort capsaicin 8% patch reversibly reduces a-delta fiber evoked potential amplitudes
topic Neuropathic
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902250/
https://www.ncbi.nlm.nih.gov/pubmed/29756090
http://dx.doi.org/10.1097/PR9.0000000000000644
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