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Early plasma monocyte chemoattractant protein 1 predicts the development of sepsis in trauma patients: A prospective observational study

Monocyte chemoattractant protein 1 (MCP-1) is an initiating cytokine of the inflammatory cascade. Extracellular MCP-1 exhibits pro-inflammatory characteristic and plays a central pathogenic role in critical illness. The purpose of the study was to identify the association between plasma MCP-1 levels...

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Autores principales: Wang, Yuchang, Liu, Qinxin, Liu, Tao, Zheng, Qiang, Xu, Xi’e, Liu, Xinghua, Gao, Wei, Li, Zhanfei, Bai, Xiangjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902265/
https://www.ncbi.nlm.nih.gov/pubmed/29620667
http://dx.doi.org/10.1097/MD.0000000000010356
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author Wang, Yuchang
Liu, Qinxin
Liu, Tao
Zheng, Qiang
Xu, Xi’e
Liu, Xinghua
Gao, Wei
Li, Zhanfei
Bai, Xiangjun
author_facet Wang, Yuchang
Liu, Qinxin
Liu, Tao
Zheng, Qiang
Xu, Xi’e
Liu, Xinghua
Gao, Wei
Li, Zhanfei
Bai, Xiangjun
author_sort Wang, Yuchang
collection PubMed
description Monocyte chemoattractant protein 1 (MCP-1) is an initiating cytokine of the inflammatory cascade. Extracellular MCP-1 exhibits pro-inflammatory characteristic and plays a central pathogenic role in critical illness. The purpose of the study was to identify the association between plasma MCP-1 levels and the development of sepsis after severe trauma. The plasma levels of MCP-1 in severe trauma patients were measured by a quantitative enzyme-linked immune sorbent assay and the dynamic release patterns were recorded at three time points during seven days post-trauma. The related factors of prognosis were compared between sepsis and non-sepsis groups and analyzed using multivariate logistic regression analysis. We also used receiver operating characteristic (ROC) curves to assess the values of different variables in predicting sepsis. A total of 72 patients who met criteria indicative of severe trauma (72.22% of male; mean age, 49.40 ± 14.29 years) were enrolled. Plasma MCP-1 concentrations significantly increased on post-trauma day 1 and that this increase was significantly correlated with the Injury Severity Score (ISS) and interleukin-6 (IL-6). Multivariate logistic regression analysis showed that early MCP-1, ISS, and IL-6 were independent risk factors for sepsis in severe trauma patients. Incorporation of the early MCP-1 into the ISS can increase the discriminative performance for predicting development of sepsis. Early plasma MCP-1 concentrations can be used to assess the severity of trauma and is correlated with the development of sepsis after severe trauma. The addition of the early MCP-1 levels to the ISS significantly improves its ability to predict development of sepsis.
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spelling pubmed-59022652018-04-24 Early plasma monocyte chemoattractant protein 1 predicts the development of sepsis in trauma patients: A prospective observational study Wang, Yuchang Liu, Qinxin Liu, Tao Zheng, Qiang Xu, Xi’e Liu, Xinghua Gao, Wei Li, Zhanfei Bai, Xiangjun Medicine (Baltimore) 3900 Monocyte chemoattractant protein 1 (MCP-1) is an initiating cytokine of the inflammatory cascade. Extracellular MCP-1 exhibits pro-inflammatory characteristic and plays a central pathogenic role in critical illness. The purpose of the study was to identify the association between plasma MCP-1 levels and the development of sepsis after severe trauma. The plasma levels of MCP-1 in severe trauma patients were measured by a quantitative enzyme-linked immune sorbent assay and the dynamic release patterns were recorded at three time points during seven days post-trauma. The related factors of prognosis were compared between sepsis and non-sepsis groups and analyzed using multivariate logistic regression analysis. We also used receiver operating characteristic (ROC) curves to assess the values of different variables in predicting sepsis. A total of 72 patients who met criteria indicative of severe trauma (72.22% of male; mean age, 49.40 ± 14.29 years) were enrolled. Plasma MCP-1 concentrations significantly increased on post-trauma day 1 and that this increase was significantly correlated with the Injury Severity Score (ISS) and interleukin-6 (IL-6). Multivariate logistic regression analysis showed that early MCP-1, ISS, and IL-6 were independent risk factors for sepsis in severe trauma patients. Incorporation of the early MCP-1 into the ISS can increase the discriminative performance for predicting development of sepsis. Early plasma MCP-1 concentrations can be used to assess the severity of trauma and is correlated with the development of sepsis after severe trauma. The addition of the early MCP-1 levels to the ISS significantly improves its ability to predict development of sepsis. Wolters Kluwer Health 2018-04-06 /pmc/articles/PMC5902265/ /pubmed/29620667 http://dx.doi.org/10.1097/MD.0000000000010356 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 3900
Wang, Yuchang
Liu, Qinxin
Liu, Tao
Zheng, Qiang
Xu, Xi’e
Liu, Xinghua
Gao, Wei
Li, Zhanfei
Bai, Xiangjun
Early plasma monocyte chemoattractant protein 1 predicts the development of sepsis in trauma patients: A prospective observational study
title Early plasma monocyte chemoattractant protein 1 predicts the development of sepsis in trauma patients: A prospective observational study
title_full Early plasma monocyte chemoattractant protein 1 predicts the development of sepsis in trauma patients: A prospective observational study
title_fullStr Early plasma monocyte chemoattractant protein 1 predicts the development of sepsis in trauma patients: A prospective observational study
title_full_unstemmed Early plasma monocyte chemoattractant protein 1 predicts the development of sepsis in trauma patients: A prospective observational study
title_short Early plasma monocyte chemoattractant protein 1 predicts the development of sepsis in trauma patients: A prospective observational study
title_sort early plasma monocyte chemoattractant protein 1 predicts the development of sepsis in trauma patients: a prospective observational study
topic 3900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902265/
https://www.ncbi.nlm.nih.gov/pubmed/29620667
http://dx.doi.org/10.1097/MD.0000000000010356
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