Cargando…
Association between PRKAA1 rs13361707 T>C polymorphism and gastric cancer risk: Evidence based on a meta-analysis
BACKGROUND: Recently, several published studies investigating the relationship between protein kinase catalytic subunit alpha-1 gene (PRKAA1) rs13361707 T>C polymorphism and gastric cancer (GC) susceptibility reported controversial results. The purpose of this meta-analysis was to estimate the st...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902272/ https://www.ncbi.nlm.nih.gov/pubmed/29620653 http://dx.doi.org/10.1097/MD.0000000000010302 |
_version_ | 1783314732324749312 |
---|---|
author | Jiang, You Li, Wenbo Lu, Jun Zhao, Xin Li, Liang |
author_facet | Jiang, You Li, Wenbo Lu, Jun Zhao, Xin Li, Liang |
author_sort | Jiang, You |
collection | PubMed |
description | BACKGROUND: Recently, several published studies investigating the relationship between protein kinase catalytic subunit alpha-1 gene (PRKAA1) rs13361707 T>C polymorphism and gastric cancer (GC) susceptibility reported controversial results. The purpose of this meta-analysis was to estimate the strength of the relationship. METHODS: Qualified studies were identified form a comprehensive search conducted in the Embase, Pubmed, Wangfang, and China National Knowledge Infrastructure (CNKI) databases for studies published before February 12, 2018. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the relationship between the PRKAA1 rs13361707 T>C polymorphism and GC risk. RESULTS: Fifteen independent case-control studies, which included 14,615 GC patients and 18,143 control subjects, were included in this present meta-analysis. The overall analysis of the 15 studies indicated that the PRKAA1 rs13361707 T>C polymorphism significantly increased susceptibility for GC in all genetic models. When stratified analysis was carried out by country and source of controls, similar results were found in each subgroup, except for the Hispanic Americans. There was no publication bias in our study. Omitting each study 1 at a time in the sensitivity analysis of the PRKAA1 rs13361707 T>C polymorphism and GC risk had no noticeable influence on the pooled OR, which identified the reliability of the meta-analysis. False-positive report probability analysis and trial sequential analysis demonstrated that such relationship was confirmed in the present study. CONCLUSIONS: The meta-analysis reveals that the PRKAA1 rs13361707 T>C polymorphism has a significant relationship with increased GC risk. To confirm the risk identified in the present meta-analysis, well-designed and large-scale case-control studies are warranted to investigate the relationship, especially among non-Asian ethnicity. |
format | Online Article Text |
id | pubmed-5902272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-59022722018-04-24 Association between PRKAA1 rs13361707 T>C polymorphism and gastric cancer risk: Evidence based on a meta-analysis Jiang, You Li, Wenbo Lu, Jun Zhao, Xin Li, Liang Medicine (Baltimore) 3500 BACKGROUND: Recently, several published studies investigating the relationship between protein kinase catalytic subunit alpha-1 gene (PRKAA1) rs13361707 T>C polymorphism and gastric cancer (GC) susceptibility reported controversial results. The purpose of this meta-analysis was to estimate the strength of the relationship. METHODS: Qualified studies were identified form a comprehensive search conducted in the Embase, Pubmed, Wangfang, and China National Knowledge Infrastructure (CNKI) databases for studies published before February 12, 2018. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the relationship between the PRKAA1 rs13361707 T>C polymorphism and GC risk. RESULTS: Fifteen independent case-control studies, which included 14,615 GC patients and 18,143 control subjects, were included in this present meta-analysis. The overall analysis of the 15 studies indicated that the PRKAA1 rs13361707 T>C polymorphism significantly increased susceptibility for GC in all genetic models. When stratified analysis was carried out by country and source of controls, similar results were found in each subgroup, except for the Hispanic Americans. There was no publication bias in our study. Omitting each study 1 at a time in the sensitivity analysis of the PRKAA1 rs13361707 T>C polymorphism and GC risk had no noticeable influence on the pooled OR, which identified the reliability of the meta-analysis. False-positive report probability analysis and trial sequential analysis demonstrated that such relationship was confirmed in the present study. CONCLUSIONS: The meta-analysis reveals that the PRKAA1 rs13361707 T>C polymorphism has a significant relationship with increased GC risk. To confirm the risk identified in the present meta-analysis, well-designed and large-scale case-control studies are warranted to investigate the relationship, especially among non-Asian ethnicity. Wolters Kluwer Health 2018-04-06 /pmc/articles/PMC5902272/ /pubmed/29620653 http://dx.doi.org/10.1097/MD.0000000000010302 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0 |
spellingShingle | 3500 Jiang, You Li, Wenbo Lu, Jun Zhao, Xin Li, Liang Association between PRKAA1 rs13361707 T>C polymorphism and gastric cancer risk: Evidence based on a meta-analysis |
title | Association between PRKAA1 rs13361707 T>C polymorphism and gastric cancer risk: Evidence based on a meta-analysis |
title_full | Association between PRKAA1 rs13361707 T>C polymorphism and gastric cancer risk: Evidence based on a meta-analysis |
title_fullStr | Association between PRKAA1 rs13361707 T>C polymorphism and gastric cancer risk: Evidence based on a meta-analysis |
title_full_unstemmed | Association between PRKAA1 rs13361707 T>C polymorphism and gastric cancer risk: Evidence based on a meta-analysis |
title_short | Association between PRKAA1 rs13361707 T>C polymorphism and gastric cancer risk: Evidence based on a meta-analysis |
title_sort | association between prkaa1 rs13361707 t>c polymorphism and gastric cancer risk: evidence based on a meta-analysis |
topic | 3500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902272/ https://www.ncbi.nlm.nih.gov/pubmed/29620653 http://dx.doi.org/10.1097/MD.0000000000010302 |
work_keys_str_mv | AT jiangyou associationbetweenprkaa1rs13361707tcpolymorphismandgastriccancerriskevidencebasedonametaanalysis AT liwenbo associationbetweenprkaa1rs13361707tcpolymorphismandgastriccancerriskevidencebasedonametaanalysis AT lujun associationbetweenprkaa1rs13361707tcpolymorphismandgastriccancerriskevidencebasedonametaanalysis AT zhaoxin associationbetweenprkaa1rs13361707tcpolymorphismandgastriccancerriskevidencebasedonametaanalysis AT liliang associationbetweenprkaa1rs13361707tcpolymorphismandgastriccancerriskevidencebasedonametaanalysis |