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Evaluation of the clinical value of hematological parameters in patients with urothelial carcinoma of the bladder

This study aimed to evaluate the clinical significance of pretreatment red cell distribution width (RDW), monocyte/lymphocyte ratio (MLR), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) in patients with urothelial carcinoma of the bladder (UCB). Hematological parameters of 12...

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Autores principales: Luo, Yuzhen, Shi, Xiang, Li, Wenchao, Mo, Lijun, Yang, Zheng, Li, Xiaohong, Qin, Liuqun, Mo, Wuning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902274/
https://www.ncbi.nlm.nih.gov/pubmed/29620666
http://dx.doi.org/10.1097/MD.0000000000010351
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author Luo, Yuzhen
Shi, Xiang
Li, Wenchao
Mo, Lijun
Yang, Zheng
Li, Xiaohong
Qin, Liuqun
Mo, Wuning
author_facet Luo, Yuzhen
Shi, Xiang
Li, Wenchao
Mo, Lijun
Yang, Zheng
Li, Xiaohong
Qin, Liuqun
Mo, Wuning
author_sort Luo, Yuzhen
collection PubMed
description This study aimed to evaluate the clinical significance of pretreatment red cell distribution width (RDW), monocyte/lymphocyte ratio (MLR), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) in patients with urothelial carcinoma of the bladder (UCB). Hematological parameters of 127 consecutive patients with UCB and 162 healthy controls were retrospectively analyzed. Receiver operating characteristic curve was plotted to determine the optimal cut-off value of RDW, MLR, NLR, and PLR to predict UCB. Whether these parameters could be independent predictors of UCB and had an association with the demographics and clinical characteristics of patients were also assessed. Patients with UCB had higher pretreatment RDW, MLR, NLR, and PLR compared with the healthy controls. With the tumor progression, MLR, NLR, and PLR rose consistently, whereas no significant difference was observed in RDW across tumor stages. NLR and PLR were associated with tumor size and tumor grade, while MLR was correlated with tumor size only. The best threshold of RDW, MLR, NLR, and PLR to predict UCB was 13.50%, 0.26, 2.16, and 128.46, respectively. Multivariate logistic regression model identified NLR ≥ 2.16 (odds ratio [OR] = 2.914; P < .001) and PLR ≥ 128.46 (OR = 2.761; P < .001) as independent predictors of UCB. High NLR and PLR were also associated with tumor markers, such as carcinoembryonic antigen and α-fetoprotein. Pretreatment NLR and PLR could be significant independent predictors of UCB. These simple and readily available inflammatory markers therefore might be used to manage the disease.
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spelling pubmed-59022742018-04-24 Evaluation of the clinical value of hematological parameters in patients with urothelial carcinoma of the bladder Luo, Yuzhen Shi, Xiang Li, Wenchao Mo, Lijun Yang, Zheng Li, Xiaohong Qin, Liuqun Mo, Wuning Medicine (Baltimore) 4100 This study aimed to evaluate the clinical significance of pretreatment red cell distribution width (RDW), monocyte/lymphocyte ratio (MLR), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) in patients with urothelial carcinoma of the bladder (UCB). Hematological parameters of 127 consecutive patients with UCB and 162 healthy controls were retrospectively analyzed. Receiver operating characteristic curve was plotted to determine the optimal cut-off value of RDW, MLR, NLR, and PLR to predict UCB. Whether these parameters could be independent predictors of UCB and had an association with the demographics and clinical characteristics of patients were also assessed. Patients with UCB had higher pretreatment RDW, MLR, NLR, and PLR compared with the healthy controls. With the tumor progression, MLR, NLR, and PLR rose consistently, whereas no significant difference was observed in RDW across tumor stages. NLR and PLR were associated with tumor size and tumor grade, while MLR was correlated with tumor size only. The best threshold of RDW, MLR, NLR, and PLR to predict UCB was 13.50%, 0.26, 2.16, and 128.46, respectively. Multivariate logistic regression model identified NLR ≥ 2.16 (odds ratio [OR] = 2.914; P < .001) and PLR ≥ 128.46 (OR = 2.761; P < .001) as independent predictors of UCB. High NLR and PLR were also associated with tumor markers, such as carcinoembryonic antigen and α-fetoprotein. Pretreatment NLR and PLR could be significant independent predictors of UCB. These simple and readily available inflammatory markers therefore might be used to manage the disease. Wolters Kluwer Health 2018-04-06 /pmc/articles/PMC5902274/ /pubmed/29620666 http://dx.doi.org/10.1097/MD.0000000000010351 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 4100
Luo, Yuzhen
Shi, Xiang
Li, Wenchao
Mo, Lijun
Yang, Zheng
Li, Xiaohong
Qin, Liuqun
Mo, Wuning
Evaluation of the clinical value of hematological parameters in patients with urothelial carcinoma of the bladder
title Evaluation of the clinical value of hematological parameters in patients with urothelial carcinoma of the bladder
title_full Evaluation of the clinical value of hematological parameters in patients with urothelial carcinoma of the bladder
title_fullStr Evaluation of the clinical value of hematological parameters in patients with urothelial carcinoma of the bladder
title_full_unstemmed Evaluation of the clinical value of hematological parameters in patients with urothelial carcinoma of the bladder
title_short Evaluation of the clinical value of hematological parameters in patients with urothelial carcinoma of the bladder
title_sort evaluation of the clinical value of hematological parameters in patients with urothelial carcinoma of the bladder
topic 4100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902274/
https://www.ncbi.nlm.nih.gov/pubmed/29620666
http://dx.doi.org/10.1097/MD.0000000000010351
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