Comparative performance of different scale‐down simulators of substrate gradients in Penicillium chrysogenum cultures: the need of a biological systems response analysis

In a 54 m(3) large‐scale penicillin fermentor, the cells experience substrate gradient cycles at the timescales of global mixing time about 20–40 s. Here, we used an intermittent feeding regime (IFR) and a two‐compartment reactor (TCR) to mimic these substrate gradients at laboratory‐scale continuou...

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Detalles Bibliográficos
Autores principales: Wang, Guan, Zhao, Junfei, Haringa, Cees, Tang, Wenjun, Xia, Jianye, Chu, Ju, Zhuang, Yingping, Zhang, Siliang, Deshmukh, Amit T., van Gulik, Walter, Heijnen, Joseph J., Noorman, Henk J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902331/
https://www.ncbi.nlm.nih.gov/pubmed/29333753
http://dx.doi.org/10.1111/1751-7915.13046

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