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RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex

The R2TP/Prefoldin-like co-chaperone, in concert with HSP90, facilitates assembly and cellular stability of RNA polymerase II, and complexes of PI3-kinase-like kinases such as mTOR. However, the mechanism by which this occurs is poorly understood. Here we use cryo-EM and biochemical studies on the h...

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Detalles Bibliográficos
Autores principales:	Martino, Fabrizio, Pal, Mohinder, Muñoz-Hernández, Hugo, Rodríguez, Carlos F., Núñez-Ramírez, Rafael, Gil-Carton, David, Degliesposti, Gianluca, Skehel, J. Mark, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence H., Llorca, Oscar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902453/ https://www.ncbi.nlm.nih.gov/pubmed/29662061 http://dx.doi.org/10.1038/s41467-018-03942-1

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