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Microdissection testicular sperm extraction in five Japanese patients with non‐mosaic Klinefelter's syndrome
CASES: Microdissection testicular sperm extraction (micro‐TESE) was performed on five Japanese men with non‐mosaic Klinefelter's syndrome (KS) and non‐obstructive azoospermia in the authors' department. Here is reported the operative results and partner's clinical course for two cases...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902470/ https://www.ncbi.nlm.nih.gov/pubmed/29692680 http://dx.doi.org/10.1002/rmb2.12092 |
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author | Chihara, Makoto Ogi, Kanna Ishiguro, Tatsuya Yoshida, Kunihiko Godo, Chikako Takakuwa, Koichi Enomoto, Takayuki |
author_facet | Chihara, Makoto Ogi, Kanna Ishiguro, Tatsuya Yoshida, Kunihiko Godo, Chikako Takakuwa, Koichi Enomoto, Takayuki |
author_sort | Chihara, Makoto |
collection | PubMed |
description | CASES: Microdissection testicular sperm extraction (micro‐TESE) was performed on five Japanese men with non‐mosaic Klinefelter's syndrome (KS) and non‐obstructive azoospermia in the authors' department. Here is reported the operative results and partner's clinical course for two cases where spermatozoa could be acquired. Also encountered was a man with non‐mosaic KS with the partial deletion of azoospermia factor (AZF)b. Because this is rare, it is reported in detail in the context of the previous literature. This case series describes the first experience of micro‐TESE by gynecologists in the current department. OUTCOME: The egg collection date was adjusted to the micro‐TESE day by using the modified ultra‐long method. Intracytoplasmic sperm injection (ICSI) was implemented for two men whose spermatozoa were acquired by micro‐TESE, with these progressing to the blastocyst stage. Subsequently, one case conceived after the transfer of fresh embryos and a healthy baby was delivered. However, spermatozoa could not be retrieved from the man with non‐mosaic KS who was harboring the partial deletion of AZFb. CONCLUSION: These findings suggest that ovulation induction by using the modified ultra‐long method with micro‐TESE and ICSI on the same day represents an effective treatment option for men with non‐mosaic KS. As there are cases where AZF deletion is recognized among patients with non‐mosaic KS, screening before micro‐TESE is strongly recommended. |
format | Online Article Text |
id | pubmed-5902470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59024702018-04-24 Microdissection testicular sperm extraction in five Japanese patients with non‐mosaic Klinefelter's syndrome Chihara, Makoto Ogi, Kanna Ishiguro, Tatsuya Yoshida, Kunihiko Godo, Chikako Takakuwa, Koichi Enomoto, Takayuki Reprod Med Biol Case Report CASES: Microdissection testicular sperm extraction (micro‐TESE) was performed on five Japanese men with non‐mosaic Klinefelter's syndrome (KS) and non‐obstructive azoospermia in the authors' department. Here is reported the operative results and partner's clinical course for two cases where spermatozoa could be acquired. Also encountered was a man with non‐mosaic KS with the partial deletion of azoospermia factor (AZF)b. Because this is rare, it is reported in detail in the context of the previous literature. This case series describes the first experience of micro‐TESE by gynecologists in the current department. OUTCOME: The egg collection date was adjusted to the micro‐TESE day by using the modified ultra‐long method. Intracytoplasmic sperm injection (ICSI) was implemented for two men whose spermatozoa were acquired by micro‐TESE, with these progressing to the blastocyst stage. Subsequently, one case conceived after the transfer of fresh embryos and a healthy baby was delivered. However, spermatozoa could not be retrieved from the man with non‐mosaic KS who was harboring the partial deletion of AZFb. CONCLUSION: These findings suggest that ovulation induction by using the modified ultra‐long method with micro‐TESE and ICSI on the same day represents an effective treatment option for men with non‐mosaic KS. As there are cases where AZF deletion is recognized among patients with non‐mosaic KS, screening before micro‐TESE is strongly recommended. John Wiley and Sons Inc. 2018-03-08 /pmc/articles/PMC5902470/ /pubmed/29692680 http://dx.doi.org/10.1002/rmb2.12092 Text en © 2018 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Case Report Chihara, Makoto Ogi, Kanna Ishiguro, Tatsuya Yoshida, Kunihiko Godo, Chikako Takakuwa, Koichi Enomoto, Takayuki Microdissection testicular sperm extraction in five Japanese patients with non‐mosaic Klinefelter's syndrome |
title | Microdissection testicular sperm extraction in five Japanese patients with non‐mosaic Klinefelter's syndrome |
title_full | Microdissection testicular sperm extraction in five Japanese patients with non‐mosaic Klinefelter's syndrome |
title_fullStr | Microdissection testicular sperm extraction in five Japanese patients with non‐mosaic Klinefelter's syndrome |
title_full_unstemmed | Microdissection testicular sperm extraction in five Japanese patients with non‐mosaic Klinefelter's syndrome |
title_short | Microdissection testicular sperm extraction in five Japanese patients with non‐mosaic Klinefelter's syndrome |
title_sort | microdissection testicular sperm extraction in five japanese patients with non‐mosaic klinefelter's syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902470/ https://www.ncbi.nlm.nih.gov/pubmed/29692680 http://dx.doi.org/10.1002/rmb2.12092 |
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