LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus

Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited clinical efficacy. Therefore, it is timely to identify innovative targets to dam...

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Detalles Bibliográficos
Autores principales: Cobo-Vuilleumier, Nadia, Lorenzo, Petra I., Rodríguez, Noelia García, Herrera Gómez, Irene de Gracia, Fuente-Martin, Esther, López-Noriega, Livia, Mellado-Gil, José Manuel, Romero-Zerbo, Silvana-Yanina, Baquié, Mathurin, Lachaud, Christian Claude, Stifter, Katja, Perdomo, German, Bugliani, Marco, De Tata, Vincenzo, Bosco, Domenico, Parnaud, Geraldine, Pozo, David, Hmadcha, Abdelkrim, Florido, Javier P., Toscano, Miguel G., de Haan, Peter, Schoonjans, Kristina, Sánchez Palazón, Luis, Marchetti, Piero, Schirmbeck, Reinhold, Martín-Montalvo, Alejandro, Meda, Paolo, Soria, Bernat, Bermúdez-Silva, Francisco-Javier, St-Onge, Luc, Gauthier, Benoit R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902555/
https://www.ncbi.nlm.nih.gov/pubmed/29662071
http://dx.doi.org/10.1038/s41467-018-03943-0

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