Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals

Aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) is implicated in the pathogenesis of sporadic and certain familial forms of amyotrophic lateral sclerosis (ALS), suggesting elimination of TDP-43 aggregates as a possible therapeutic strategy. Here we generated and investigated a single-chain...

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Detalles Bibliográficos
Autores principales: Tamaki, Yoshitaka, Shodai, Akemi, Morimura, Toshifumi, Hikiami, Ryota, Minamiyama, Sumio, Ayaki, Takashi, Tooyama, Ikuo, Furukawa, Yoshiaki, Takahashi, Ryosuke, Urushitani, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902603/
https://www.ncbi.nlm.nih.gov/pubmed/29662239
http://dx.doi.org/10.1038/s41598-018-24463-3

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