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Modulation of Hoogsteen dynamics on DNA recognition

In naked duplex DNA, G–C and A–T Watson-Crick base pairs exist in dynamic equilibrium with their Hoogsteen counterparts. Here, we used nuclear magnetic resonance (NMR) relaxation dispersion and molecular dynamics (MD) simulations to examine how Watson-Crick/Hoogsteen dynamics are modulated upon reco...

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Detalles Bibliográficos
Autores principales:	Xu, Yu, McSally, James, Andricioaei, Ioan, Al-Hashimi, Hashim M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902632/ https://www.ncbi.nlm.nih.gov/pubmed/29662229 http://dx.doi.org/10.1038/s41467-018-03516-1

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