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Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes
Solid-state Nuclear magnetic resonance, thermogravimetric analysis, X-ray diffraction, and Fourier-transform infrared spectroscopy were combined with theoretical calculation to investigate different crystal packings of α-cefazolin sodium obtained from three different vendors and conformational polym...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902681/ https://www.ncbi.nlm.nih.gov/pubmed/29692988 http://dx.doi.org/10.3389/fchem.2018.00113 |
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author | Tian, Ye Wang, Wei D. Zou, Wen-Bo Qian, Jian-Qin Hu, Chang-Qin |
author_facet | Tian, Ye Wang, Wei D. Zou, Wen-Bo Qian, Jian-Qin Hu, Chang-Qin |
author_sort | Tian, Ye |
collection | PubMed |
description | Solid-state Nuclear magnetic resonance, thermogravimetric analysis, X-ray diffraction, and Fourier-transform infrared spectroscopy were combined with theoretical calculation to investigate different crystal packings of α-cefazolin sodium obtained from three different vendors and conformational polymorphism was identified to exist in α-cefazolin sodium. Marginal differences observed among cefazolin sodium pentahydrate 1, 2, and 3 were speculated as being caused by the proportion of conformation 2. |
format | Online Article Text |
id | pubmed-5902681 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59026812018-04-24 Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes Tian, Ye Wang, Wei D. Zou, Wen-Bo Qian, Jian-Qin Hu, Chang-Qin Front Chem Chemistry Solid-state Nuclear magnetic resonance, thermogravimetric analysis, X-ray diffraction, and Fourier-transform infrared spectroscopy were combined with theoretical calculation to investigate different crystal packings of α-cefazolin sodium obtained from three different vendors and conformational polymorphism was identified to exist in α-cefazolin sodium. Marginal differences observed among cefazolin sodium pentahydrate 1, 2, and 3 were speculated as being caused by the proportion of conformation 2. Frontiers Media S.A. 2018-04-10 /pmc/articles/PMC5902681/ /pubmed/29692988 http://dx.doi.org/10.3389/fchem.2018.00113 Text en Copyright © 2018 Tian, Wang, Zou, Qian and Hu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Tian, Ye Wang, Wei D. Zou, Wen-Bo Qian, Jian-Qin Hu, Chang-Qin Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes |
title | Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes |
title_full | Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes |
title_fullStr | Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes |
title_full_unstemmed | Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes |
title_short | Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes |
title_sort | application of solid-state nmr to reveal structural differences in cefazolin sodium pentahydrate from different manufacturing processes |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902681/ https://www.ncbi.nlm.nih.gov/pubmed/29692988 http://dx.doi.org/10.3389/fchem.2018.00113 |
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