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Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes

Solid-state Nuclear magnetic resonance, thermogravimetric analysis, X-ray diffraction, and Fourier-transform infrared spectroscopy were combined with theoretical calculation to investigate different crystal packings of α-cefazolin sodium obtained from three different vendors and conformational polym...

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Detalles Bibliográficos
Autores principales: Tian, Ye, Wang, Wei D., Zou, Wen-Bo, Qian, Jian-Qin, Hu, Chang-Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902681/
https://www.ncbi.nlm.nih.gov/pubmed/29692988
http://dx.doi.org/10.3389/fchem.2018.00113
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author Tian, Ye
Wang, Wei D.
Zou, Wen-Bo
Qian, Jian-Qin
Hu, Chang-Qin
author_facet Tian, Ye
Wang, Wei D.
Zou, Wen-Bo
Qian, Jian-Qin
Hu, Chang-Qin
author_sort Tian, Ye
collection PubMed
description Solid-state Nuclear magnetic resonance, thermogravimetric analysis, X-ray diffraction, and Fourier-transform infrared spectroscopy were combined with theoretical calculation to investigate different crystal packings of α-cefazolin sodium obtained from three different vendors and conformational polymorphism was identified to exist in α-cefazolin sodium. Marginal differences observed among cefazolin sodium pentahydrate 1, 2, and 3 were speculated as being caused by the proportion of conformation 2.
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spelling pubmed-59026812018-04-24 Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes Tian, Ye Wang, Wei D. Zou, Wen-Bo Qian, Jian-Qin Hu, Chang-Qin Front Chem Chemistry Solid-state Nuclear magnetic resonance, thermogravimetric analysis, X-ray diffraction, and Fourier-transform infrared spectroscopy were combined with theoretical calculation to investigate different crystal packings of α-cefazolin sodium obtained from three different vendors and conformational polymorphism was identified to exist in α-cefazolin sodium. Marginal differences observed among cefazolin sodium pentahydrate 1, 2, and 3 were speculated as being caused by the proportion of conformation 2. Frontiers Media S.A. 2018-04-10 /pmc/articles/PMC5902681/ /pubmed/29692988 http://dx.doi.org/10.3389/fchem.2018.00113 Text en Copyright © 2018 Tian, Wang, Zou, Qian and Hu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Tian, Ye
Wang, Wei D.
Zou, Wen-Bo
Qian, Jian-Qin
Hu, Chang-Qin
Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes
title Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes
title_full Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes
title_fullStr Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes
title_full_unstemmed Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes
title_short Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes
title_sort application of solid-state nmr to reveal structural differences in cefazolin sodium pentahydrate from different manufacturing processes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902681/
https://www.ncbi.nlm.nih.gov/pubmed/29692988
http://dx.doi.org/10.3389/fchem.2018.00113
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