Vagus Nerve Stimulation (VNS) and Other Augmentation Strategies for Therapy-Resistant Depression (TRD): Review of the Evidence and Clinical Advice for Use

In addition to electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), vagus nerve stimulation (VNS) is one of the approved neurostimulation tools for treatment of major depression. VNS is particularly used in therapy-resistant depression (TRD) and exhibits antidepre...

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Autores principales: Müller, Helge H. O., Moeller, Sebastian, Lücke, Caroline, Lam, Alexandra P., Braun, Niclas, Philipsen, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902793/
https://www.ncbi.nlm.nih.gov/pubmed/29692707
http://dx.doi.org/10.3389/fnins.2018.00239
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author Müller, Helge H. O.
Moeller, Sebastian
Lücke, Caroline
Lam, Alexandra P.
Braun, Niclas
Philipsen, Alexandra
author_facet Müller, Helge H. O.
Moeller, Sebastian
Lücke, Caroline
Lam, Alexandra P.
Braun, Niclas
Philipsen, Alexandra
author_sort Müller, Helge H. O.
collection PubMed
description In addition to electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), vagus nerve stimulation (VNS) is one of the approved neurostimulation tools for treatment of major depression. VNS is particularly used in therapy-resistant depression (TRD) and exhibits antidepressive and augmentative effects. In long-term treatment, up to two-thirds of patients respond. This mini-review provides a comprehensive overview of augmentation pharmacotherapy and neurostimulation-based treatment strategies, with a special focus on VNS in TRD, and provides practical clinical advice for how to select TRD patients for add-on neurostimulation treatment strategies.
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spelling pubmed-59027932018-04-24 Vagus Nerve Stimulation (VNS) and Other Augmentation Strategies for Therapy-Resistant Depression (TRD): Review of the Evidence and Clinical Advice for Use Müller, Helge H. O. Moeller, Sebastian Lücke, Caroline Lam, Alexandra P. Braun, Niclas Philipsen, Alexandra Front Neurosci Neuroscience In addition to electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), vagus nerve stimulation (VNS) is one of the approved neurostimulation tools for treatment of major depression. VNS is particularly used in therapy-resistant depression (TRD) and exhibits antidepressive and augmentative effects. In long-term treatment, up to two-thirds of patients respond. This mini-review provides a comprehensive overview of augmentation pharmacotherapy and neurostimulation-based treatment strategies, with a special focus on VNS in TRD, and provides practical clinical advice for how to select TRD patients for add-on neurostimulation treatment strategies. Frontiers Media S.A. 2018-04-10 /pmc/articles/PMC5902793/ /pubmed/29692707 http://dx.doi.org/10.3389/fnins.2018.00239 Text en Copyright © 2018 Müller, Moeller, Lücke, Lam, Braun and Philipsen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Müller, Helge H. O.
Moeller, Sebastian
Lücke, Caroline
Lam, Alexandra P.
Braun, Niclas
Philipsen, Alexandra
Vagus Nerve Stimulation (VNS) and Other Augmentation Strategies for Therapy-Resistant Depression (TRD): Review of the Evidence and Clinical Advice for Use
title Vagus Nerve Stimulation (VNS) and Other Augmentation Strategies for Therapy-Resistant Depression (TRD): Review of the Evidence and Clinical Advice for Use
title_full Vagus Nerve Stimulation (VNS) and Other Augmentation Strategies for Therapy-Resistant Depression (TRD): Review of the Evidence and Clinical Advice for Use
title_fullStr Vagus Nerve Stimulation (VNS) and Other Augmentation Strategies for Therapy-Resistant Depression (TRD): Review of the Evidence and Clinical Advice for Use
title_full_unstemmed Vagus Nerve Stimulation (VNS) and Other Augmentation Strategies for Therapy-Resistant Depression (TRD): Review of the Evidence and Clinical Advice for Use
title_short Vagus Nerve Stimulation (VNS) and Other Augmentation Strategies for Therapy-Resistant Depression (TRD): Review of the Evidence and Clinical Advice for Use
title_sort vagus nerve stimulation (vns) and other augmentation strategies for therapy-resistant depression (trd): review of the evidence and clinical advice for use
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902793/
https://www.ncbi.nlm.nih.gov/pubmed/29692707
http://dx.doi.org/10.3389/fnins.2018.00239
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