Palmitoylation-dependent activation of MC1R prevents melanomagenesis

The melanocortin-1 receptor (MC1R), a G protein-coupled receptor, plays a crucial role in human and mouse pigmentation(1–8). Activation of MC1R in melanocytes by α-melanocyte-stimulating hormone (α-MSH)(9) stimulates cAMP signaling and melanin production and enhances DNA repair after UV irradiation...

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Detalles Bibliográficos
Autores principales: Chen, Shuyang, Zhu, Bo, Yin, Chengqian, Liu, Wei, Han, Changpeng, Chen, Baoen, Liu, Tongzheng, Li, Xin, Chen, Xiang, Li, Chunying, Hu, Limin, Zhou, Jun, Xu, Zhi-Xiang, Gao, Xiumei, Wu, Xu, Goding, Colin R., Cui, Rutao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902815/
https://www.ncbi.nlm.nih.gov/pubmed/28869973
http://dx.doi.org/10.1038/nature23887

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