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Genome-Wide Analysis to Identify HLA Factors Potentially Associated With Severe Dengue
The pathogenesis of dengue hemorrhagic fever (DHF), following dengue virus (DENV) infection, is a complex and poorly understood phenomenon. In view of the clinical need of identifying patients with higher likelihood of developing this severe outcome, we undertook a comparative genome-wide associatio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902865/ https://www.ncbi.nlm.nih.gov/pubmed/29692780 http://dx.doi.org/10.3389/fimmu.2018.00728 |
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author | Gupta, Sudheer Agarwal, Ankita Kumar, Amod Biswas, Debasis |
author_facet | Gupta, Sudheer Agarwal, Ankita Kumar, Amod Biswas, Debasis |
author_sort | Gupta, Sudheer |
collection | PubMed |
description | The pathogenesis of dengue hemorrhagic fever (DHF), following dengue virus (DENV) infection, is a complex and poorly understood phenomenon. In view of the clinical need of identifying patients with higher likelihood of developing this severe outcome, we undertook a comparative genome-wide association analysis of epitope variants from sequences available in the ViPR database that have been reported to be differentially related to dengue fever and DHF. Having enumerated the incriminated epitope variants, we determined the corresponding HLA alleles in the context of which DENV infection could potentially precipitate DHF. Our analysis considered the development of DHF in three different perspectives: (a) as a consequence of primary DENV infection, (b) following secondary DENV infection with a heterologous serotype, (c) as a result of DENV infection following infection with related flaviviruses like Zika virus, Japanese Encephalitis virus, West Nile virus, etc. Subject to experimental validation, these viral and host markers would be valuable in triaging DENV-infected patients for closer supervision owing to the relatively higher risk of poor prognostic outcome and also for the judicious allocation of scarce institutional resources during large outbreaks. |
format | Online Article Text |
id | pubmed-5902865 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59028652018-04-24 Genome-Wide Analysis to Identify HLA Factors Potentially Associated With Severe Dengue Gupta, Sudheer Agarwal, Ankita Kumar, Amod Biswas, Debasis Front Immunol Immunology The pathogenesis of dengue hemorrhagic fever (DHF), following dengue virus (DENV) infection, is a complex and poorly understood phenomenon. In view of the clinical need of identifying patients with higher likelihood of developing this severe outcome, we undertook a comparative genome-wide association analysis of epitope variants from sequences available in the ViPR database that have been reported to be differentially related to dengue fever and DHF. Having enumerated the incriminated epitope variants, we determined the corresponding HLA alleles in the context of which DENV infection could potentially precipitate DHF. Our analysis considered the development of DHF in three different perspectives: (a) as a consequence of primary DENV infection, (b) following secondary DENV infection with a heterologous serotype, (c) as a result of DENV infection following infection with related flaviviruses like Zika virus, Japanese Encephalitis virus, West Nile virus, etc. Subject to experimental validation, these viral and host markers would be valuable in triaging DENV-infected patients for closer supervision owing to the relatively higher risk of poor prognostic outcome and also for the judicious allocation of scarce institutional resources during large outbreaks. Frontiers Media S.A. 2018-04-10 /pmc/articles/PMC5902865/ /pubmed/29692780 http://dx.doi.org/10.3389/fimmu.2018.00728 Text en Copyright © 2018 Gupta, Agarwal, Kumar and Biswas. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Gupta, Sudheer Agarwal, Ankita Kumar, Amod Biswas, Debasis Genome-Wide Analysis to Identify HLA Factors Potentially Associated With Severe Dengue |
title | Genome-Wide Analysis to Identify HLA Factors Potentially Associated With Severe Dengue |
title_full | Genome-Wide Analysis to Identify HLA Factors Potentially Associated With Severe Dengue |
title_fullStr | Genome-Wide Analysis to Identify HLA Factors Potentially Associated With Severe Dengue |
title_full_unstemmed | Genome-Wide Analysis to Identify HLA Factors Potentially Associated With Severe Dengue |
title_short | Genome-Wide Analysis to Identify HLA Factors Potentially Associated With Severe Dengue |
title_sort | genome-wide analysis to identify hla factors potentially associated with severe dengue |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902865/ https://www.ncbi.nlm.nih.gov/pubmed/29692780 http://dx.doi.org/10.3389/fimmu.2018.00728 |
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