Cargando…

Valproic acid sensitizes metformin-resistant human renal cell carcinoma cells by upregulating H3 acetylation and EMT reversal

BACKGROUND: Metformin (Met) is a widely available diabetic drug and shows suppressed effects on renal cell carcinoma (RCC) metabolism and proliferation. Laboratory studies in RCC suggested that metformin has remarkable antitumor activities and seems to be a potential antitumor drug. But the facts th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Muyun, Mao, Shaowei, Lu, Guoliang, Li, Liang, Lan, Xiaopeng, Huang, Zhongxian, Chen, Yougen, Zhao, Miaoqing, Zhao, Yueran, Xia, Qinghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902941/ https://www.ncbi.nlm.nih.gov/pubmed/29665787 http://dx.doi.org/10.1186/s12885-018-4344-3

Ejemplares similares

FKBP51 promotes invasion and migration by increasing the autophagic degradation of TIMP3 in clear cell renal cell carcinoma
por: Mao, Shaowei, et al.
Publicado: (2021)

Valproic acid induces autophagy by suppressing the Akt/mTOR pathway in human prostate cancer cells
por: Xia, Qinghua, et al.
Publicado: (2016)

TRIM11 Upregulation Contributes to Proliferation, Invasion, and EMT of Hepatocellular Carcinoma Cells
por: Zhang, Zewei, et al.
Publicado: (2017)

Metformin sensitizes hypoxia-induced gefitinib treatment resistance of HNSCC via cell cycle regulation and EMT reversal
por: Yin, Xiteng, et al.
Publicado: (2018)

Metformin induces protein acetylation in cancer cells
por: Vancura, Ales, et al.
Publicado: (2017)

Metformin Increases the Chemosensitivity of Pancreatic Cancer Cells to Gemcitabine by Reversing EMT Through Regulation DNA Methylation of miR-663
por: Gu, Yuqing, et al.
Publicado: (2020)

Hypoxia-related LncRNAs signature predicts prognosis and is associated with immune infiltration and progress of head and neck squamous cell carcinoma
por: Li, Minhan, et al.
Publicado: (2022)

HDAC inhibitor valproic acid upregulates CAR in vitro and in vivo
por: Segura-Pacheco, Blanca, et al.
Publicado: (2007)

Glycolysis mediates neuron specific histone acetylation in valproic acid-induced human excitatory neuron differentiation
por: Chen, Andi, et al.
Publicado: (2023)

Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line
por: Yagi, Yasumichi, et al.
Publicado: (2010)

FBXL10 promotes EMT and metastasis of breast cancer cells via regulating the acetylation and transcriptional activity of SNAI1
por: Yang, Yangyang, et al.
Publicado: (2021)

Metformin reverses prostate cancer resistance to enzalutamide by targeting TGF-β1/STAT3 axis-regulated EMT
por: Liu, Qiuli, et al.
Publicado: (2017)

Increased expression of fatty acid synthase and acetyl-CoA carboxylase in the prefrontal cortex and cerebellum in the valproic acid model of autism
por: Chen, Jianling, et al.
Publicado: (2016)

Author Correction: FBXL10 promotes EMT and metastasis of breast cancer cells via regulating the acetylation and transcriptional activity of SNAI1
por: Yang, Yangyang, et al.
Publicado: (2022)

Evaluation of acetylation and methylation in oral rinse of patients with head and neck cancer history exposed to valproic acid
por: Gama, Ricardo Ribeiro, et al.
Publicado: (2021)

Changes in chromatin accessibility landscape and histone H3 core acetylation during valproic acid-induced differentiation of embryonic stem cells
por: Baumann, Claudia, et al.
Publicado: (2021)

MicroRNA-210-3p is transcriptionally upregulated by hypoxia induction and thus promoting EMT and chemoresistance in glioma cells
por: Liu, Hong, et al.
Publicado: (2021)

The HPA/SDC1 axis promotes invasion and metastasis of pancreatic cancer cells by activating EMT via FGF2 upregulation
por: Chen, Xidong, et al.
Publicado: (2020)

Valproic acid inhibits proliferation of HER2-expressing breast cancer cells by inducing cell cycle arrest and apoptosis through Hsp70 acetylation
por: MAWATARI, TOSHIKI, et al.
Publicado: (2015)

Valproic acid inhibits the invasion of PC3 prostate cancer cells by upregulating the metastasis suppressor protein NDRG1
por: Lee, Jae Eun, et al.
Publicado: (2015)

Epigenetically Upregulated T-Type Calcium Channels Contribute to Abnormal Proliferation of Embryonic Neural Progenitor Cells Exposed to Valproic Acid
por: Kim, Ji-Woon, et al.
Publicado: (2020)

LncRNA PNKY Is Upregulated in Breast Cancer and Promotes Cell Proliferation and EMT in Breast Cancer Cells
por: Hakiminia, Forough, et al.
Publicado: (2023)

Transplantation of mesenchymal stem cells reverses behavioural deficits and impaired neurogenesis caused by prenatal exposure to valproic acid
por: Gobshtis, Nikolai, et al.
Publicado: (2017)

Role of Histone Acetylation in the Stimulatory Effect of Valproic Acid on Vascular Endothelial Tissue-Type Plasminogen Activator Expression
por: Larsson, Pia, et al.
Publicado: (2012)

Upregulation of LSD1 promotes migration and invasion in gastric cancer through facilitating EMT
por: Zhang, Jin, et al.
Publicado: (2019)

Dexamethasone Sensitizes Acute Monocytic Leukemia Cells to Ara-C by Upregulating FKBP51
por: Sun, Huanxin, et al.
Publicado: (2022)

Valproic Acid Induces Telomerase Reverse Transcriptase Expression during Cortical Development
por: Kim, Ki Chan, et al.
Publicado: (2017)

Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer
por: Zhang, Baotong, et al.
Publicado: (2021)

Inhibition of leukemic cells by valproic acid, an HDAC inhibitor, in xenograft tumors
por: Zhang, Zhihua, et al.
Publicado: (2013)

Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress
por: Wu, Chung-Che, et al.
Publicado: (2018)

Valproic acid upregulates NKG2D ligand expression and enhances susceptibility of human renal carcinoma cells to NK cell-mediated cytotoxicity
por: Yang, Fengqiang, et al.
Publicado: (2013)

Downregulation of microRNA-4324 promotes the EMT of esophageal squamous-cell carcinoma cells via upregulating FAK
por: Zhou, Jian, et al.
Publicado: (2019)

Upregulation of MDR- and EMT-Related Molecules in Cisplatin-Resistant Human Oral Squamous Cell Carcinoma Cell Lines
por: Choi, Hyeong Sim, et al.
Publicado: (2019)

FKBP51 decreases cell proliferation and increases progestin sensitivity of human endometrial adenocarcinomas by inhibiting Akt
por: Dong, Jing, et al.
Publicado: (2017)

Competitive endogenous RNA is an intrinsic component of EMT regulatory circuits and modulates EMT
por: Liu, Yuwei, et al.
Publicado: (2019)

Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation
por: Fang, Yili, et al.
Publicado: (2020)

Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells
por: DU, RUIXIA, et al.
Publicado: (2016)

Erratum: Valproic Acid Induces Telomerase Reverse Transcriptase Expression during Cortical Development
por: Kim, Ki Chan, et al.
Publicado: (2017)

Upregulation of oncogenic MUC1 by the EMT transcription factor brachyury mediates immunotherapy-resistance in tumor cells
por: David, Justin M, et al.
Publicado: (2015)

Valproic Acid Inhibits Glioma and Its Mechanisms
por: Yang, Zhao-Yu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_agjr0is4nj4p64v1qumg2qh9t7