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Comparison of Mutagenic Activities of Various Ultra-Fine Particles
Air pollution is increasing, along with consumption of fossil fuels such as coal and diesel gas. Air pollutants are known to be a major cause of respiratory-related illness and death, however, there are few reports on the genotoxic characterization of diverse air pollutants in Korea. In this study,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Toxicology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903137/ https://www.ncbi.nlm.nih.gov/pubmed/29686778 http://dx.doi.org/10.5487/TR.2018.34.2.163 |
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author | Park, Chang Gyun Cho, Hyun Ki Shin, Han Jae Park, Ki Hong Lim, Heung Bin |
author_facet | Park, Chang Gyun Cho, Hyun Ki Shin, Han Jae Park, Ki Hong Lim, Heung Bin |
author_sort | Park, Chang Gyun |
collection | PubMed |
description | Air pollution is increasing, along with consumption of fossil fuels such as coal and diesel gas. Air pollutants are known to be a major cause of respiratory-related illness and death, however, there are few reports on the genotoxic characterization of diverse air pollutants in Korea. In this study, we investigated the mutagenic activity of various particles such as diesel exhaust particles (DEP), combustion of rice straw (RSC), pine stem (PSC), and coal (CC), tunnel dust (TD), and road side dust (RD). Ultra-fine particles (UFPs) were collected by the glass fiber filter pad. Then, we performed a chemical analysis to see each of the component features of each particulate matter. The mutagenicity of various UFPs was determined by the Ames test with four Salmonella typhimurium strains with or without metabolic activation. The optimal concentrations of UFPs were selected based on result of a concentration decision test. Moreover, in order to compare relative mutagenicity among UFPs, we selected and tested DEP as mutation reference. DEP, RSC, and PSC induced concentration-dependent increases in revertant colony numbers with TA98, TA100, and TA1537 strains in the absence and presence of metabolic activation. DEP showed the highest specific activity among the particulate matters. In this study, we conclude that DEP, RSC, PSC, and TD displayed varying degrees of mutagenicity, and these results suggest that the mutagenicity of these air pollutants is associated with the presence of polycyclic aromatic hydrocarbons (PAHs) in these particulate matters. |
format | Online Article Text |
id | pubmed-5903137 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Society of Toxicology |
record_format | MEDLINE/PubMed |
spelling | pubmed-59031372018-04-23 Comparison of Mutagenic Activities of Various Ultra-Fine Particles Park, Chang Gyun Cho, Hyun Ki Shin, Han Jae Park, Ki Hong Lim, Heung Bin Toxicol Res Original Article Air pollution is increasing, along with consumption of fossil fuels such as coal and diesel gas. Air pollutants are known to be a major cause of respiratory-related illness and death, however, there are few reports on the genotoxic characterization of diverse air pollutants in Korea. In this study, we investigated the mutagenic activity of various particles such as diesel exhaust particles (DEP), combustion of rice straw (RSC), pine stem (PSC), and coal (CC), tunnel dust (TD), and road side dust (RD). Ultra-fine particles (UFPs) were collected by the glass fiber filter pad. Then, we performed a chemical analysis to see each of the component features of each particulate matter. The mutagenicity of various UFPs was determined by the Ames test with four Salmonella typhimurium strains with or without metabolic activation. The optimal concentrations of UFPs were selected based on result of a concentration decision test. Moreover, in order to compare relative mutagenicity among UFPs, we selected and tested DEP as mutation reference. DEP, RSC, and PSC induced concentration-dependent increases in revertant colony numbers with TA98, TA100, and TA1537 strains in the absence and presence of metabolic activation. DEP showed the highest specific activity among the particulate matters. In this study, we conclude that DEP, RSC, PSC, and TD displayed varying degrees of mutagenicity, and these results suggest that the mutagenicity of these air pollutants is associated with the presence of polycyclic aromatic hydrocarbons (PAHs) in these particulate matters. Korean Society of Toxicology 2018-04 2018-04-15 /pmc/articles/PMC5903137/ /pubmed/29686778 http://dx.doi.org/10.5487/TR.2018.34.2.163 Text en Copyright © 2018 The Korean Society Of Toxicology http://creativecommons.org/licenses/by-nc/3.0 This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, Chang Gyun Cho, Hyun Ki Shin, Han Jae Park, Ki Hong Lim, Heung Bin Comparison of Mutagenic Activities of Various Ultra-Fine Particles |
title | Comparison of Mutagenic Activities of Various Ultra-Fine Particles |
title_full | Comparison of Mutagenic Activities of Various Ultra-Fine Particles |
title_fullStr | Comparison of Mutagenic Activities of Various Ultra-Fine Particles |
title_full_unstemmed | Comparison of Mutagenic Activities of Various Ultra-Fine Particles |
title_short | Comparison of Mutagenic Activities of Various Ultra-Fine Particles |
title_sort | comparison of mutagenic activities of various ultra-fine particles |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903137/ https://www.ncbi.nlm.nih.gov/pubmed/29686778 http://dx.doi.org/10.5487/TR.2018.34.2.163 |
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