Two Cases of Severe Tick-Borne Encephalitis in Rituximab-Treated Patients in Germany: Implications for Diagnosis and Prevention

Rituximab (RTX) has become a standard therapy for certain B cell malignancies and autoimmune diseases. We report 2 RTX-treated patients who developed severe tick-borne encephalitis virus (TBEV) infection. The inability to generate new antibody responses renders RTX-treated patients susceptible to TB...

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Autores principales: Steininger, Philipp A, Bobinger, Tobias, Dietrich, Wenke, Lee, De-Hyung, Knott, Michael, Bogdan, Christian, Korn, Klaus, Lang, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
ID Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903409/
https://www.ncbi.nlm.nih.gov/pubmed/29670929
http://dx.doi.org/10.1093/ofid/ofx204
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author Steininger, Philipp A
Bobinger, Tobias
Dietrich, Wenke
Lee, De-Hyung
Knott, Michael
Bogdan, Christian
Korn, Klaus
Lang, Roland
author_facet Steininger, Philipp A
Bobinger, Tobias
Dietrich, Wenke
Lee, De-Hyung
Knott, Michael
Bogdan, Christian
Korn, Klaus
Lang, Roland
author_sort Steininger, Philipp A
collection PubMed
description Rituximab (RTX) has become a standard therapy for certain B cell malignancies and autoimmune diseases. We report 2 RTX-treated patients who developed severe tick-borne encephalitis virus (TBEV) infection. The inability to generate new antibody responses renders RTX-treated patients susceptible to TBEV, impedes laboratory diagnosis, and necessitates preventive vaccination in endemic areas.
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spelling pubmed-59034092018-04-18 Two Cases of Severe Tick-Borne Encephalitis in Rituximab-Treated Patients in Germany: Implications for Diagnosis and Prevention Steininger, Philipp A Bobinger, Tobias Dietrich, Wenke Lee, De-Hyung Knott, Michael Bogdan, Christian Korn, Klaus Lang, Roland Open Forum Infect Dis ID Case Rituximab (RTX) has become a standard therapy for certain B cell malignancies and autoimmune diseases. We report 2 RTX-treated patients who developed severe tick-borne encephalitis virus (TBEV) infection. The inability to generate new antibody responses renders RTX-treated patients susceptible to TBEV, impedes laboratory diagnosis, and necessitates preventive vaccination in endemic areas. Oxford University Press 2017-09-26 /pmc/articles/PMC5903409/ /pubmed/29670929 http://dx.doi.org/10.1093/ofid/ofx204 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle ID Case
Steininger, Philipp A
Bobinger, Tobias
Dietrich, Wenke
Lee, De-Hyung
Knott, Michael
Bogdan, Christian
Korn, Klaus
Lang, Roland
Two Cases of Severe Tick-Borne Encephalitis in Rituximab-Treated Patients in Germany: Implications for Diagnosis and Prevention
title Two Cases of Severe Tick-Borne Encephalitis in Rituximab-Treated Patients in Germany: Implications for Diagnosis and Prevention
title_full Two Cases of Severe Tick-Borne Encephalitis in Rituximab-Treated Patients in Germany: Implications for Diagnosis and Prevention
title_fullStr Two Cases of Severe Tick-Borne Encephalitis in Rituximab-Treated Patients in Germany: Implications for Diagnosis and Prevention
title_full_unstemmed Two Cases of Severe Tick-Borne Encephalitis in Rituximab-Treated Patients in Germany: Implications for Diagnosis and Prevention
title_short Two Cases of Severe Tick-Borne Encephalitis in Rituximab-Treated Patients in Germany: Implications for Diagnosis and Prevention
title_sort two cases of severe tick-borne encephalitis in rituximab-treated patients in germany: implications for diagnosis and prevention
topic ID Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903409/
https://www.ncbi.nlm.nih.gov/pubmed/29670929
http://dx.doi.org/10.1093/ofid/ofx204
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